Genetic variants within the endotoxin signaling pathway and asthma: an association study

Buyuktiryaki, B.
Topaloglu, E.
Yaman, A.
Atalay, Rengül
Atalay, Mehmet Volkan
Sackesen, C.
Kalayci, O.


Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation.
Ishii, KJ; Takeshita, F; Gursel, I; Gürsel, Mayda; Conover, J; Nussenzweig, A; Klinman, DM (Rockefeller University Press, 2002-07-15)
Unmethylated CpG motifs present in bacterial DNA stimulate a strong innate immune response. There is evidence that DNA-dependent protein kinase (DNA-PK) mediates CpG signaling. Specifically, wortmannin (an inhibitor of phosphatidylinositol 3 kinase [PI3]-kinases including DNA-PK) interferes with CpG-dependent cell activation, and DNA-PK knockout (KO) mice fail to respond to CpG stimulation. Current studies establish that wortmannin actually inhibits the uptake and colocalization of CpG DNA with toll-like re...
Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer
Chaabane, Wiem; User, Sirma D.; El-Gazzah, Mohamed; Jaksik, Roman; Sajjadi, Elaheh; Rzeszowska-Wolny, Joanna; Los, Marek J. (Springer Science and Business Media LLC, 2013-02-01)
Cell death is a fundamental ingredient of life. Thus, not surprisingly more than one form of cell death exists. Several excellent reviews on various forms of cell death have already been published but manuscripts describing interconnection and interdependence between such processes are uncommon. Here, what follows is a brief introduction on all three classical forms of cell death, followed by a more detailed insight into the role of p53, the master regulator of apoptosis, and other forms of cell death. Whil...
Inhibition of the TIRAP-c-Jun interaction as a therapeutic strategy for AP1-mediated inflammatory responses
Srivastava, Mansi; Saqib, Uzma; Banerjee, Sreeparna; Wary, Kishore; Kizil, Burak; Muthu, Kannan; Baig, Mirza S. (Elsevier BV, 2019-06-01)
Bacterial endotoxin-induced sepsis causes 30-40% of the deaths in the intensive care unit (ICU) globally, for which there is no pharmacotherapy. Lipopolysaccharide (LPS), a bacterial endotoxin, stimulates the Toll-like receptor (TLR)-4 signalling pathways to upregulate the expression of various inflammatory mediators. Here, we show that the TIRAP and c-Jun protein signalling complex forms in macrophages in response to LPS stimulation, which increases the AP1 transcriptional activity, thereby amplifying the ...
Interleukin-15 acts as an immunological co-adjuvant for liposomal antigen in vivo
Gürsel, Mayda (Elsevier BV, 1997-03-01)
The recently discovered interleukin-15 (IL-15) is known to bind to the receptor of interleukin-2 (IL-2) and to share several of the latter's immunological properties. In the present study, the first to our knowledge on IL-15 behaviour in vivo, we examined the possibility that IL-15 also shares the ability of IL-2 to enhance the immunological adjuvant property of liposomes by acting as a co-adjuvant. The cytokine and a model antigen (tetanus toroid) were either co-entrapped by the dehydration rehydration met...
Two cases and two particular signs of thoracic outlet syndrome: tremor and tachycardia
ÖZÇAKAR, LEVENT; Ertan, Hayri; KAYMAK, BAYRAM (Springer Science and Business Media LLC, 2008-12-01)
Citation Formats
Ü. M. ŞAHİNER et al., “Genetic variants within the endotoxin signaling pathway and asthma: an association study,” 2011, vol. 66, Accessed: 00, 2020. [Online]. Available: