Cyber-physical-based PAT (CPbPAT) framework for Pharma 4.0

Date

2019-08-01

Author

VATANKHAH BARENJI, REZA
Akdag, Yagmur
Yet, Barbaros
ÖNER, LEVENT

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Industry 4.0 aims to integrate manufacturing operations into a seamless digital whole by incorporating flexibility, agility, re-configurability, and sustainability. The result of this integration is a "smart factory" that is more lean, agile, and flexible in operations. There are valid reasons, and perhaps requirements, for pharmaceutical industries to embrace smart factory and to "borrow" the concept of Industry 4.0 to give rise to "Pharma 4.0" (i.e., the pharmaceutical version of Industry 4.0). This paper proposes a cyber-physical-based PAT framework called CPbPAT for implementing smart manufacturing systems in the pharmaceutical industry. The framework has been developed using an agent-based system and is presented by a standard system modeling language called the Unified Modeling Language (UML). The pharmaceutical manufacturing system shown in "Quality by Design for ANDAs" is used as a case study to illustrate the application of the proposed framework.

Subject Keywords

Pharmaceutical Science

URI

https://hdl.handle.net/11511/56607

Journal

INTERNATIONAL JOURNAL OF PHARMACEUTICS

DOI

https://doi.org/10.1016/j.ijpharm.2019.06.036

Collections

Graduate School of Informatics, Article

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Citation Formats

R. VATANKHAH BARENJI, Y. Akdag, B. Yet, and L. ÖNER, “Cyber-physical-based PAT (CPbPAT) framework for Pharma 4.0,” INTERNATIONAL JOURNAL OF PHARMACEUTICS, pp. 0–0, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56607.