Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities

Date

2014-01-01

Author

Hossain, Mohammad Shakhawoat
POLAT ÇAKIR, SIDIKA
Karaduman, Ayse Betul
YAMAÇ, MUSTAFA
Demir, Ayhan Sıtkı

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A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl) aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

Subject Keywords

Acyl Phosphonates, Alkynyl Organoaluminum, Propargylic Alcohols, Tris-(Phenylethynyl)Aluminum, Tris-(Propynyl)Aluminum, Antimicrobial Activity

URI

https://hdl.handle.net/11511/56691

Journal

TURKISH JOURNAL OF CHEMISTRY

DOI

https://doi.org/10.3906/kim-1402-6

Collections

Department of Chemistry, Article

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Citation Formats

M. S. Hossain, S. POLAT ÇAKIR, A. B. Karaduman, M. YAMAÇ, and A. S. Demir, “Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities,” TURKISH JOURNAL OF CHEMISTRY, pp. 880–893, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56691.