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Carbocyclic 4'-epi-formycin
Date
2008-01-01
Author
Zhou, Jian
Yang, Minmin
Akdağ, Akın
Wang, Haisheng
Schneller, Stewart W.
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4'-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells.
Subject Keywords
Organic Chemistry
,
Biochemistry
,
Drug Discovery
URI
https://hdl.handle.net/11511/56829
Journal
TETRAHEDRON
DOI
https://doi.org/10.1016/j.tet.2007.10.054
Collections
Department of Chemistry, Article