Carbocyclic 4'-epi-formycin

Date

2008-01-01

Author

Zhou, Jian
Yang, Minmin
Akdağ, Akın
Wang, Haisheng
Schneller, Stewart W.

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Formycin is a naturally occurring biologically responsive C-nucleoside. In pursuing the design and syntheses of novel C-nucleosides, convenient access to carbocyclic C-nucleosides based on the formycin framework was a goal. One such target was carbocyclic 4'-epi-formycin (4). This compound is reported via a procedure based on an asymmetric aldol/ring closure metathesis strategy. To provide a preliminary glimpse into the biological characterization of 4 an antiviral assay was conducted. Target 4 was found to be inactive and to lack cytotoxicity to the host cells.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/56829

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2007.10.054

Collections

Department of Chemistry, Article

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Citation Formats

J. Zhou, M. Yang, A. Akdağ, H. Wang, and S. W. Schneller, “Carbocyclic 4′-epi-formycin,” TETRAHEDRON, pp. 433–438, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56829.