C-4 ' Truncated carbocyclic formycin derivatives

Date

2006-07-01

Author

Zhou, Jian
Yang, Minmin
Akdağ, Akın
Schneller, Stewart W.

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Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-4' hydroxylmethylene moiety in racemic form (4 and 6, respectively). An antiviral analysis of (+/-)-4 did not disclose any activity.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/56201

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2006.04.068

Collections

Department of Chemistry, Article

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Citation Formats

J. Zhou, M. Yang, A. Akdağ, and S. W. Schneller, “C-4 ′ Truncated carbocyclic formycin derivatives,” TETRAHEDRON, pp. 7009–7013, 2006, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56201.