A new and stereospecific synthesis of an inositol analogue: bis-homoinositol

Kara, Y
Balcı, Metin
The photooxygenation of trans-8-(acetyloxy)bicyclo[4.2.0]octa-2,4-dien-7-yl acetate afforded the bicyclic endoperoxide. Reduction of the endoperoxide with thiourea followed by acetylation gave the corresponding tetraacetate. The KMnO4 oxidation of the tetraacetate followed by acetylation gave dihydroxytetraacetate Ammonolysis of tetraacetate afforded the bis-homoinositol, bicyclo[4.2.0]octane-2,3,4,5,7,8-hexol.


A new antiaromatic compound: 1,4-biphenylenequinone synthesis and trapping reactions: can a quinone unit stabilize the cyclobutadiene?
Kilic, H; Balcı, Metin (2001-12-03)
The photooxygenation of 4a,8b-dihydrobiphenylene affords an endoperoxide. NEt3-catalyzed rearrangement of this endoperoxide gave the corresponding hydroxy enone, while the CoTPP-catalyzed rearrangement afforded a bisepoxide. MnO2 oxidation of hydroxy enol leads to 4a,8b-dihydrobiphenylene-1,4-dione. The NIBS bromination of this dione produces mono- and dibromides. NEt3-supported elimination of monobromide and zinc elimination of dibromide afforded the target compound, 1,4-biphenylenequinone, which was trapp...
A theoretical study on camptothecin-AM1 treatment
Türker, Burhan Lemi (2001-08-13)
Camptothecin (irinotecan), a new cytotoxic agent having antitumor activity and especially used in the treatment of advanced colorectal cancers is considered for AM1-RBF type semiempirical quantum chemical treatment together with some analogs of camptothecin. The structural properties and energetics of these molecules have been compared. The structures arising from monoprotonation of camptothecin at various sites are analyzed from thermodynamic point of view.
Challenges in line-of-balance scheduling
Arditi, David; Tokdemir, Onur Behzat; Suh, Kangsuk (American Society of Civil Engineers (ASCE), 2002-11-01)
The line-of-balance ~LOB! method of scheduling is well suited to projects that are composed of activities of a linear and repetitive nature. The objective of this study is to set down the basic principles that can be used in the development of a computerized LOB scheduling system that overcomes the problems associated with existing systems and creates solutions to problems encountered in the implementation of repetitive-unit construction. The challenges associated with LOB scheduling include developing an a...
A primary investigation of nutrient residues on the soils of citrus orchards in Güzelyurt
Forsuh, Peter Atungsiri; Saurin, Julian; Tokay, Begüm; Sustainable Environment and Energy Systems (2013-5)
The non-point (defused) source pollution of agrochemicals on soils; surface water and ground water may be a driving force of environmental degradation and may also pose risks to human health. This thesis seeks to address concerns about environmental sustainability in agriculture systems by undertaking a first baseline study of agrichemical residues - such as nitrate, nitrite, potash, and phosphates - on the soils of citrus orchards in Guzelyurt district. The methods applied in this study are both quantitati...
Reaction of pentacarbonyl(eta(2)-bis(trimethylsilyl)ethyne)tungsten(0) with tricyclohexylphosphine: X-ray structure of pentacarbonyltricyclohexylphosphinetungsten(0)
Demircan, O; Özkar, Saim; Ulku, D; Yildirim, LT (2003-12-15)
The pentacarbonyl(?(2)-bis(trimethylsilyl)ethyne)tungsten(0), W(CO)(5)(?(2)-btmse), reacts with tricyclohexylphosphine, PCy3, to yield two stable endproducts which could be isolated and fully characterized by using the single crystal X-ray diffractometry and the MS, IR, and NMR spectroscopy: W(CO)(5)(PCy3) and trans-W(CO)(4)(PCy3)(2). The former complex is the alkyne substitution product, while the latter one is formed from the conversion of its labile cis-isomer, which is generated by further reaction of t...
Citation Formats
Y. Kara and M. Balcı, “A new and stereospecific synthesis of an inositol analogue: bis-homoinositol,” TETRAHEDRON, pp. 2063–2066, 2003, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57146.