A theoretical study on camptothecin-AM1 treatment

Date

2001-08-13

Author

Türker, Burhan Lemi

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Camptothecin (irinotecan), a new cytotoxic agent having antitumor activity and especially used in the treatment of advanced colorectal cancers is considered for AM1-RBF type semiempirical quantum chemical treatment together with some analogs of camptothecin. The structural properties and energetics of these molecules have been compared. The structures arising from monoprotonation of camptothecin at various sites are analyzed from thermodynamic point of view.

Subject Keywords

Camptothecin, Irinotecan, Campto, Camptothecin derivatives, Cytotoxic agent

URI

https://hdl.handle.net/11511/62263

Journal

JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

DOI

https://doi.org/10.1016/s0166-1280(01)00548-6

Collections

Department of Chemistry, Article

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Citation Formats

B. L. Türker, “A theoretical study on camptothecin-AM1 treatment,” JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, pp. 275–283, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62263.