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A theoretical study on camptothecin-AM1 treatment
Date
2001-08-13
Author
Türker, Burhan Lemi
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Camptothecin (irinotecan), a new cytotoxic agent having antitumor activity and especially used in the treatment of advanced colorectal cancers is considered for AM1-RBF type semiempirical quantum chemical treatment together with some analogs of camptothecin. The structural properties and energetics of these molecules have been compared. The structures arising from monoprotonation of camptothecin at various sites are analyzed from thermodynamic point of view.
Subject Keywords
Camptothecin
,
Irinotecan
,
Campto
,
Camptothecin derivatives
,
Cytotoxic agent
URI
https://hdl.handle.net/11511/62263
Journal
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
DOI
https://doi.org/10.1016/s0166-1280(01)00548-6
Collections
Department of Chemistry, Article
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B. L. Türker, “A theoretical study on camptothecin-AM1 treatment,”
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
, pp. 275–283, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62263.