A theoretical study on camptothecin-AM1 treatment

Türker, Burhan Lemi
Camptothecin (irinotecan), a new cytotoxic agent having antitumor activity and especially used in the treatment of advanced colorectal cancers is considered for AM1-RBF type semiempirical quantum chemical treatment together with some analogs of camptothecin. The structural properties and energetics of these molecules have been compared. The structures arising from monoprotonation of camptothecin at various sites are analyzed from thermodynamic point of view.


Covalent immobilization of alpha-amylase onto poly(2-hydroxyethyl methacrylate) and poly(styrene-2-hydroxyethyl methacrylate) microspheres and the effect of Ca2+ ions on the enzyme activity
Tumturk, H; Aksoy, S; Hasırcı, Nesrin (2000-02-01)
alpha-Amylase (1,4-alpha-D-glucan-glucanohydrolase; EC, Type VI-B from porcine pancreas, extra pure 29 units mg(-1)) was covalently immobilized on poly (2-hydroxyethyl methacrylate), p(HEMA), and poly (styrene-2-hydroxyethyl methacrylate), p(St-HEMA) microspheres, which were activated by using epichlorohydrin (ECH). The properties of the immobilized enzyme were investigated and compared with those of the free enzyme. For the assays carried out at 25 degrees C and pH 6.9, the relative activities were...
Evaluation of the Protective Effects of Quercetin, Rutin, Naringenin, Resveratrol and Trolox Against Idarubicin-Induced DNA Damage
Çelik, Haydar; Arinç, Emel (University of Alberta Libraries, 2010-7-22)
<jats:p>PURPOSE. Idarubicin is a synthetic anthracycline anticancer drug widely used in the treatment of some hematological malignancies. The studies in our laboratory have clearly demonstrated that idarubicin can undergo reductive bioactivation by NADPH-cytochrome P450 reductase to free radicals with resulting formation of DNA strand breaks, which can potentially contribute to its genotoxic effects [Çelik, H., Arinç, E., Bioreduction of idarubicin and formation of ROS responsible for DNA cleavage by NADPH-...
Modeling dissolved oxygen dynamics and hypoxia
Peña, M. A.; Katsev, S.; Oguz, T.; Gilbert, D. (Copernicus GmbH, 2010-3-9)
<jats:p>Abstract. Hypoxia conditions are increasing throughout the world, influencing biogeochemical cycles of elements and marine life. Hypoxia results from complex interactions between physical and biogeochemical processes, which can not be understood by observations alone. Models are invaluable tools at studying system dynamics, generalizing discrete observations and predicting future states. They are also useful as management tools for evaluating site-specific responses to management scenarios. Here we ...
Modelling seasonal circulation and thermohaline structure of the Caspian Sea
Gunduz, M.; Özsoy, E. (Copernicus GmbH, 2014-6-10)
<jats:p>Abstract. The wind- and buoyancy-driven seasonal circulation of the Caspian Sea is investigated for a better understanding of its basin-wide and mesoscale dynamics, mixing and transport. The model successfully reproduces the following basic elements of the circulation: the southward-flowing current systems along the eastern and western coasts, the upwelling along the eastern coast, the cyclonic circulation in the Middle Caspian Sea (MCS), especially in winter, and the cyclonic and anticyclonic cells...
Modelling of Advective Transport and Biogeochemistry at a Shallow Hydrothermal Vent System
Bartlett, Stuart; Giovannelli, Donato; Yücel, Mustafa (2017-08-18)
Inthisworkwepresentthefirstinaseriesofmodelresultsaimedatelucidatingthecomplexcouplingsbetweenfluidflow,heattransport,advectivetransportofsolutes,andmicrobialmatgrowthatashallowhydrothermalvent.WeareprimarilyinterestedintheventsystemsofMilos,Greece,wherebiofilmcommunitiesarespatiallysegregatedintodistinctdomains,eachwithaverydifferentspeciescomposition[1].Thelocationsofthesedomainsvarystronglywiththesandbedtopography.Inparticular,therearesharpspeciescompositiondifferencesbetweenthewindwardsideand the leewar...
Citation Formats
B. L. Türker, “A theoretical study on camptothecin-AM1 treatment,” JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, pp. 275–283, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62263.