Study of asymmetric aldol and Mannich reactions catalyzed by proline-thiourea host-guest complexes in nonpolar solvents

Date

2013-04-30

Author

Demir, Ayhan Sıtkı
BAŞÇEKEN, SİNAN

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A proline-thiourea host-guest complex has been described as a good catalyst for asymmetric reactions such as aldol and Mannich reactions. High stereoselectivities were obtained under optimal conditions. Thiourea was observed to have an important effect on the reactivity and selectivity, even in an unconventional nonpolar reaction medium and without the need to utilize low temperatures. This proline-thiourea host-guest system has the ability to participate in a hydrogen bonding network.

Subject Keywords

Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/57272

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2013.03.014

Collections

Department of Chemistry, Article

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Citation Formats

A. S. Demir and S. BAŞÇEKEN, “Study of asymmetric aldol and Mannich reactions catalyzed by proline-thiourea host-guest complexes in nonpolar solvents,” TETRAHEDRON-ASYMMETRY, pp. 515–525, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57272.