Nonlinear effects in proline-thiourea host-guest complex catalyzed aldol reactions in nonpolar solvents

Date

2010-03-16

Author

Demir, Ayhan Sıtkı
Eymur, Serkan

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An aldol reaction catalyzed by a proline-thiourea host-guest complex in a nonpolar solvent shows excellent nonlinear effects. This proline-thiourea system has the ability to form a hydrogen-bonding network. The enantiomeric excess of proline in a solution can be significantly enhanced by its incorporation with a urea molecule into its solid racemate. This suggests a general and facile route to homochirality, which may be involved in the origin of chirality on earth.

Subject Keywords

Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/62659

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2010.02.009

Collections

Department of Chemistry, Article

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Citation Formats

A. S. Demir and S. Eymur, “Nonlinear effects in proline-thiourea host-guest complex catalyzed aldol reactions in nonpolar solvents,” TETRAHEDRON-ASYMMETRY, pp. 405–409, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62659.