Synthesis of Furo[2,3-d]pyridazin-4(5H)-one and Its N(5)-Substituted Derivatives

Date

2014-11-01

Author

Karahan, Emrah
Koza, Gani
Balcı, Metin

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We report the efficient preparation of furo[2,3-d] pyridazin-4(5H)-one and its N-substituted derivatives starting from methyl 2-methylfuran-3-carboxylate. The Me group was converted to the aldehyde group, which was then condensed with hydrazine derivatives. Then, the ester functionalities were hydrolyzed to the corresponding acids, followed by treatment with SOCl2 to give N-substituted furopyridazinone derivatives.

Subject Keywords

Phthalazinones , Pyridazines , Furans, Pyrroles

URI

https://hdl.handle.net/11511/57382

Journal

HELVETICA CHIMICA ACTA

DOI

https://doi.org/10.1002/hlca.201400042

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

E. Karahan, G. Koza, and M. Balcı, “Synthesis of Furo[2,3-d]pyridazin-4(5H)-one and Its N(5)-Substituted Derivatives,” HELVETICA CHIMICA ACTA, pp. 1487–1496, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57382.