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Immunoproteomic analysis of Bordetella pertussis and identification of new immunogenic proteins
Date
2009-01-22
Author
Altindis, Emrah
Tefon, Burcu E.
Yildirim, Volkan
Ozcengiz, Erkan
Becher, Doete
Hecker, Michael
Özcengiz, Gülay
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Bordetella pertussis is the causative agent of highly communicable respiratory infection whooping cough (pertussis) which remains one of the world's leading causes of vaccine-preventable deaths. In the present study, total soluble proteins extracted from two B. pertussis strains, Tohama I and the local isolate Saadet were separated by two-dimensional gel electrophoresis and analyzed by Western blotting for their reactivity with the antisera obtained from the mice immunized with inactivated whole cells as well as those collected from the mice challenged intraperitoneally with live cells of each strain. Of a total of 25 immunogenic proteins identified, 21 were shown to be the novel antigens for B. pertussis.
Subject Keywords
Public Health, Environmental and Occupational Health
,
General Immunology and Microbiology
,
Molecular Medicine
,
General Veterinary
,
Infectious Diseases
URI
https://hdl.handle.net/11511/57688
Journal
VACCINE
DOI
https://doi.org/10.1016/j.vaccine.2008.11.020
Collections
Department of Biology, Article
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E. Altindis et al., “Immunoproteomic analysis of Bordetella pertussis and identification of new immunogenic proteins,”
VACCINE
, pp. 542–548, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57688.