Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
A new ZTL-type F-box functions as a positive regulator in disease resistance: VIGS analysis in barley against powdery mildew
Date
2009-01-01
Author
Dagdas, Yasin Fatih
Dagdas, Gulay
Unver, Turgay
Akkaya, Mahinur
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
137
views
0
downloads
Cite This
In our previous studies, we found a new Zeitlupe (ZTL) type F-box protein which is expressed at a higher level upon avirulent pathogen infection (Bozkurt et al., 2007). F-box proteins mark the proteins to be degraded through 26S proteasome system by ubiquitination. Since the information on the role of ubiquitin mediated proteolysis in disease responses is advancing rapidly, we sought to understand the way which F-box functions in resistance response as part of ubiquitin-proteasome pathway. Interestingly, in response to silencing of this F-box gene via BSMV mediated virus induced gene silencing (VIGS) method, barley plants lost resistance towards avirulent pathogen race. The Pallas-01 line having Mla1 R-gene showed hyphae formations when inoculated with avirulent powdery mildew race, Bgh103, after 4-fold silencing. This observation suggests that F-box protein functions as a positive regulator in powdery mildew disease mechanism and broadens the function of ZTL-type F-box proteins, previously known to have roles only in circadian clocks, flowering time control, and phytochrome pathway.
Subject Keywords
IGS
,
Disease related F-box protein
,
Hordeum vulgare
,
Ubiquitination
,
Powdery mildew
,
BSMV
,
E3 ligase
URI
https://hdl.handle.net/11511/57743
Journal
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
DOI
https://doi.org/10.1016/j.pmpp.2009.08.003
Collections
Graduate School of Natural and Applied Sciences, Article
Suggestions
OpenMETU
Core
The facile synthesis of cyclopentanoid antibiotic kjellmanianone
Demir, Ayhan Sıtkı; Tanyeli, Cihangir; Gulbeyaz, V; Akgul, H (1996-01-01)
The synthesis of cyclopentanoid antibiotic Kjellmanianone is described in this study. The C-acylation of lithium enolates of 3-Methoxycyclopentenone by N-carbomethoxyimidazole or methylcyanoformate beta-ketoester, which when oxidized with Mn(III) acetate produces kjellmanianone in good yield.
Multiple drug resistance patterns and plasmid profiles of non-typhi salmonellae in Turkey
Yildirmak, T; Yazgan, A; Özcengiz, Gülay (1998-10-01)
A total of 259 clinical isolates of nonrepetitive non-typhi salmonellae (NTS) were examined for antibiotic resistance patterns and plasmid content. The antibiotics used were amoxicillin-clavulanic acid (AMC), ampicillin (AM), aztreonam (ATM), carbenicillin (CB), cefixime (CFM), cefotaxime (CTX), cefoxitin (FOX), ceftazidime (CAZ), ceftriaxone (CRO), chloramphenicol (C), ciprofloxacin (CIP), gentamicin (GM), imipenem (IPM), ofloxacin (OFX), tetracycline (TE), trimethoprim-sulfomethoxazole (SXT). Multi-drug r...
Antifungal spectrum determination of the K5 type yeast killer protein on fungi causing spoilage in citrus fruits
Kepekçi, Remziye Aysun; İzgü, Kadri Fatih; Department of Biology (2006)
Some yeast strains under certain conditions secrete polypeptide toxins which are inhibitory to sensitive fungal cells into the medium. These yeast strains are termed as killer yeasts and their toxins are designated as killer proteins or killer toxins. Killer proteins are classified into 11 typical types (K1-K11). These toxins have different killing mechanisms on sensitive cells. Some of them hydrolyze major cell wall component, beta-1,3- glucans. As mammalian cells lack cell walls research and development o...
The Q41R mutation in the HCV-protease enhances the reactivity towards MAVS by suppressing non-reactive pathways
Zheng, Chen; Schneider, Markus; Marıon, Antoıne; Antes, Iris (2022-01-01)
Recent experimental findings pointed out a new mutation in the HCV protease, Q41R, responsible for a significant enhancement of the enzyme's reactivity towards the mitochondrial antiviral-signaling protein (MAVS). The Q41R mutation is located rather far from the active site, and its involvement in the overall reaction mechanism is thus unclear. We used classical molecular dynamics and QM/MM to study the acylation reaction of HCV NS3/4A protease variants bound to MAVS and the NS4A/4B substrate and uncovered ...
Prediction of the effects of single amino acid variations on protein functionality with structural and annotation centric modeling
Cankara, Fatma; Tunçbağ, Nurcan; Department of Bioinformatics (2020)
Whole-genome and exome sequencing studies have indicated that genomic variations may cause deleterious effects on protein functionality via various mechanisms. Single nucleotide variations that alter the protein sequence, and thus, the structure and the function, namely non-synonymous SNPs (nsSNP), are associated with many genetic diseases in human. The current rate of manually annotating the reported nsSNPs cannot catch up with the rate of producing new sequencing data. To aid this process, automated compu...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
Y. F. Dagdas, G. Dagdas, T. Unver, and M. Akkaya, “A new ZTL-type F-box functions as a positive regulator in disease resistance: VIGS analysis in barley against powdery mildew,”
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
, pp. 41–44, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57743.