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Concentration-dependent effect of melatonin on DSPC membrane
Date
2013-11-25
Author
ŞAHİN, İPEK
Bilge, Duygu
KAZANCI, NADİDE
Severcan, Feride
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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The concentration-induced effects of melatonin on distearoyl phosphatidylcholine (DSPC) model membranes were investigated by using two different non-invasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). An investigation of the C-H, C=O and PO2- double bond stretching mode in FTIR spectra and DSC studies reveals that the inclusion of melatonin changes the physical properties of the DSPC multilamellar liposomes (MLVs) by shifting the main phase transition to lower temperatures, abolishing the pretransition, ordering the system in the gel phase and slightly disordering the system in the liquid crystalline phase, increasing the dynamics both in the gel phase and liquid crystalline phases. Melatonin also causes strong hydrogen bonding between C=O and PO2- groups of lipids and the water molecules around.
Subject Keywords
Inorganic Chemistry
,
Organic Chemistry
,
Analytical Chemistry
,
Spectroscopy
URI
https://hdl.handle.net/11511/57786
Journal
JOURNAL OF MOLECULAR STRUCTURE
DOI
https://doi.org/10.1016/j.molstruc.2013.08.060
Collections
Department of Biology, Article
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İ. ŞAHİN, D. Bilge, N. KAZANCI, and F. Severcan, “Concentration-dependent effect of melatonin on DSPC membrane,”
JOURNAL OF MOLECULAR STRUCTURE
, pp. 183–188, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57786.