Concentration-dependent effect of melatonin on DSPC membrane

Date

2013-11-25

Author

ŞAHİN, İPEK
Bilge, Duygu
KAZANCI, NADİDE
Severcan, Feride

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The concentration-induced effects of melatonin on distearoyl phosphatidylcholine (DSPC) model membranes were investigated by using two different non-invasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). An investigation of the C-H, C=O and PO2- double bond stretching mode in FTIR spectra and DSC studies reveals that the inclusion of melatonin changes the physical properties of the DSPC multilamellar liposomes (MLVs) by shifting the main phase transition to lower temperatures, abolishing the pretransition, ordering the system in the gel phase and slightly disordering the system in the liquid crystalline phase, increasing the dynamics both in the gel phase and liquid crystalline phases. Melatonin also causes strong hydrogen bonding between C=O and PO2- groups of lipids and the water molecules around.

Subject Keywords

Inorganic Chemistry, Organic Chemistry, Analytical Chemistry, Spectroscopy

URI

https://hdl.handle.net/11511/57786

Journal

JOURNAL OF MOLECULAR STRUCTURE

DOI

https://doi.org/10.1016/j.molstruc.2013.08.060

Collections

Department of Biology, Article

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Citation Formats

İ. ŞAHİN, D. Bilge, N. KAZANCI, and F. Severcan, “Concentration-dependent effect of melatonin on DSPC membrane,” JOURNAL OF MOLECULAR STRUCTURE, pp. 183–188, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57786.