Three-Dimensional Reconstruction of Human Corneas by Tissue Engineering (CORNEA ENGINEERING)

Download

CORDIS_article_89075-Result in brief.pdf
CORDIS_project_504017_en-Fact sheet.pdf
CORDIS_project_504017_Report.pdf

Date

2007-12-31

Author

Hasırcı, Vasıf Nejat

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

169
views

48
downloads

The goal of the proposed research project is to reconstruct a human cornea in vitro, for use both in corneal grafting and as an alternative to animal models for cosmeto-pharmacotoxicity testing. The project responds to the urgent need to develop new forms of corneal replacements as alternatives to the use of donor corneas, in view of the worldwide shortage of donors, the increasing risk of transmissible diseases, the widespread use of corrective surgery, which renders corneas unsuitable for grafting, and the severe limitations of currently available synthetic polymer-based artificial corneas (keratoprostheses). The originality of the proposal lies in the use of recombinant human extra cellular matrix proteins to build a engineered-engineered scaffold to support growth of the different cell types found in the cornea, cells to be derived from human adult stem cell pools. The development of a reconstructed human cornea will represent a real breakthrough, allowing diseased or damaged corneas to be replaced by tissue-engineered human corneal equivalents that resemble in all respects their natural counterparts. The proposal also responds to impending ED legislation banning the marketing of cosmetic products that have been tested on animals, using procedures such as the Raise rabbit eye irritation test. The development of tissue-engineered corneas will provide a non-animal alternative, which will therefore alleviate animal suffering. The project will lead to a transformation of industry to meet societal needs using innovative, knowledge-based approaches integrating Nan technology and biotechnology. The project brings together 14 participants with complementary expertise from 9 different countries, including basic scientists, ophthalmologists and industrialists (three Sees). Ethical and standardisation aspects will also be included.

Subject Keywords

Tissue engineering, New biomimetic and bio-hybrid systems

URI

https://cordis.europa.eu/project/id/504017
https://hdl.handle.net/11511/58459

Collections

Department of Biology, Project and Design

Suggestions

OpenMETU
Core

Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds (EXPERTISSUES) Hasırcı, Vasıf Nejat(2010-7-31) The main aim of the proposed network of excellence (Noël) is to combat and overcome fragmentation of European Research on the field of Tissue Engineering of Bone and Cartilage. The network will bring together Europe's leading academic centres and several complementary industrial players in a multi-disciplinary consortium to conduct and structure research that is able to compete in the internationally arena, namely with USA and Japan. The constitution of this network of excellence will lead to a complete res...
Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds (EXPERTISSUES) Atımtay, Aysel(2010-7-31) The main aim of the proposed network of excellence (Noël) is to combat and overcome fragmentation of European Research on the field of Tissue Engineering of Bone and Cartilage. The network will bring together Europe's leading academic centres and several complementary industrial players in a multi-disciplinary consortium to conduct and structure research that is able to compete in the internationally arena, namely with USA and Japan. The constitution of this network of excellence will lead to a complete res...
Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds (EXPERTISSUES) Hasırcı, Vasıf Nejat(2010-7-31) The main aim of the proposed network of excellence (Noël) is to combat and overcome fragmentation of European Research on the field of Tissue Engineering of Bone and Cartilage. The network will bring together Europe's leading academic centres and several complementary industrial players in a multi-disciplinary consortium to conduct and structure research that is able to compete in the internationally arena, namely with USA and Japan. The constitution of this network of excellence will lead to a complete res...
Bone tissue engineering on patterned collagen films: an in vitro study Ber, S; Kose, GT; Hasırcı, Vasıf Nejat (2005-05-01) This study aimed at guiding osteoblast cells from rat bone marrow on chemically modified and patterned collagen films to study the influence of pattern, on cell guidance. The films were stabilized using different treatment methods including crosslinking with carbodiimide (EDC) and glutaraldehyde, dehydrothermal treatment (DHT), and deposition of calcium phosphate on the collagen membrane.
Automatic segmentation of human facial tissue by MRI-CT fusion: A feasibility study Kale, Emre H.; Mumcuoğlu, Ünal Erkan; HAMCAN, Salih (2012-12-01) The aim of this study was to develop automatic image segmentation methods to segment human facial tissue which contains very thin anatomic structures. The segmentation output can be used to construct a more realistic human face model for a variety of purposes like surgery planning, patient specific prosthesis design and facial expression simulation. Segmentation methods developed were based on Bayesian and Level Set frameworks, which were applied on three image types: magnetic resonance imaging (MRI), compu...

Citation Formats

V. N. Hasırcı, “Three-Dimensional Reconstruction of Human Corneas by Tissue Engineering (CORNEA ENGINEERING),” 2007. Accessed: 00, 2020. [Online]. Available: https://cordis.europa.eu/project/id/504017.