Concentratıon Dependent Effects Of Celecoxibe On Model Membranes

Date

2009-12-31

Author

Banerjee, Sreeparna

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

188
views

0
downloads

Celecoxib is a new generation non-steroidal anti- inflammatory drug that selectively inhibits cyclooxygenase-2 and has reduced side effects because of its selectivity. Celecoxib has also been shown to have anti-cancer activity in several cancer types but its action of mechanism is not well understood. Since biological membranes are extremely complex structures, studying the effects of drugs on simple model membranes would be a convenient way to investigate drug-membrane interactions. Fourier Transform Infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and turbidity are three non-invasive techniques that give information about the structure, thermotropic phase behavior and dynamics of the membranes. The purpose of the study is to investigate the effects of celecoxib on 1,2-Distearoyl-sn-Glycero- 3-Phosphocholine (DSPC) model membranes as a function of temperature and celecoxib concentration, using FTIR spectroscopy, DSC and turbidity at 440 nm, thereby gain information about the interaction of this drug with biological membranes. This would also help us to understand the action mechanisms of celecoxib other than COX-2 inhibition.

URI

https://hdl.handle.net/11511/59821

Collections

Graduate School of Natural and Applied Sciences, Project and Design

Suggestions

OpenMETU
Core

Enantioselective formal synthesis of pregabalin with bifunctional acid/base organocatalysts Kapucu, Merve; Tanyeli, Cihangir; Department of Chemistry (2013) Pregabalin, which is marketed under the brand name of Lyrica by Pfizer, is an important chiral drug in the treatment of epilepsy and neuropathic pain. Since only S-Pregabalin is active for the treatment, asymmetric synthesis was accomplished in 6 steps and the chiral induction was done by transition metal catalysis in industrial production. In this thesis, we applied an alternative synthetic route taken place in 3 steps. The key step comprised the chiral induction done by organocatalysis and the formal asym...
Functional Application Of İmmununoliposomes Encapsulating Celecoxib On Colon Cancer Cell Lines. Banerjee, Sreeparna(2010-12-31) Long term regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been correlated with reduced risk of variety of cancers. Celecoxib is a new generation NSAID that can selectively inhibit activity of cyclooxygenase-2 (COX-2) Celecoxib serves as a chemopreventive agent in colorectal cancer. Therefore there is growing interest in developing drug delivery systems for celecoxib, Targeting will be carried out by conjugation of a chimeric monoclonal antibody (Cetuximab) against the Epidermal Growth Fac...
Investigation of the Therapeutic Effects of Palbociclib Conjugated Magnetic Nanoparticles on Different Types of Breast Cancer Cell Lines Parsian, Maryam; MUTLU, PELİN; Taghavi Pourianazar, Negar; Yalcin Azarkan, Serap; Gündüz, Ufuk (2023-01-01) Introduction: Drug targeting and controlled drug release systems in cancer treatment have many advantages over conventional chemotherapy in terms of limiting systemic toxicity, side effects, and overcoming drug resistance. Methods and Results: In this paper, fabricating nanoscale delivery system composed of magnetic nanoparticles (MNPs) covered with poly-amidoamine (PAMAM) dendrimers and using its advantages were fully used to help the chemotherapeutic drug, Palbociclib, effectively reach tumors, specifical...
Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery Tansik, Gulistan; YAKAR, ARZU; Gündüz, Ufuk (2013-12-07) One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells, which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale-based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an exter...
Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors Hawash, Mohammed; Jaradat, Nidal; Abualhasan, Murad; ŞÜKÜROĞLU, MURAT KADİR; Qaoud, Mohammed T.; Kahraman, Deniz Cansen; Daraghmeh, Heba; Maslamani, Leen; Sawafta, Mais; Ratrout, Ala; Issa, Linda (2023-12-01) Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly used class of medications worldwide for the last three decades. Objectives: This study aimed to design and synthesize a novel series of methoxyphenyl thiazole carboxamide derivatives and evaluate their cyclooxygenase (COX) suppressant and cytotoxic properties. Methods: The synthesized compounds were characterized using 1H, 13C-NMR, IR, and HRMS spectrum analysis and were evaluated for their selectivity towards COX-1 and CO...

Citation Formats

S. Banerjee, “Concentratıon Dependent Effects Of Celecoxibe On Model Membranes,” 2009. Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/59821.