Concentratıon Dependent Effects Of Celecoxibe On Model Membranes

Celecoxib is a new generation non-steroidal anti- inflammatory drug that selectively inhibits cyclooxygenase-2 and has reduced side effects because of its selectivity. Celecoxib has also been shown to have anti-cancer activity in several cancer types but its action of mechanism is not well understood. Since biological membranes are extremely complex structures, studying the effects of drugs on simple model membranes would be a convenient way to investigate drug-membrane interactions. Fourier Transform Infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and turbidity are three non-invasive techniques that give information about the structure, thermotropic phase behavior and dynamics of the membranes. The purpose of the study is to investigate the effects of celecoxib on 1,2-Distearoyl-sn-Glycero- 3-Phosphocholine (DSPC) model membranes as a function of temperature and celecoxib concentration, using FTIR spectroscopy, DSC and turbidity at 440 nm, thereby gain information about the interaction of this drug with biological membranes. This would also help us to understand the action mechanisms of celecoxib other than COX-2 inhibition.


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Pregabalin, which is marketed under the brand name of Lyrica by Pfizer, is an important chiral drug in the treatment of epilepsy and neuropathic pain. Since only S-Pregabalin is active for the treatment, asymmetric synthesis was accomplished in 6 steps and the chiral induction was done by transition metal catalysis in industrial production. In this thesis, we applied an alternative synthetic route taken place in 3 steps. The key step comprised the chiral induction done by organocatalysis and the formal asym...
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Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors
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Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly used class of medications worldwide for the last three decades. Objectives: This study aimed to design and synthesize a novel series of methoxyphenyl thiazole carboxamide derivatives and evaluate their cyclooxygenase (COX) suppressant and cytotoxic properties. Methods: The synthesized compounds were characterized using 1H, 13C-NMR, IR, and HRMS spectrum analysis and were evaluated for their selectivity towards COX-1 and CO...
Citation Formats
S. Banerjee, “Concentratıon Dependent Effects Of Celecoxibe On Model Membranes,” 2009. Accessed: 00, 2020. [Online]. Available: