Hide/Show Apps

Concentratıon Dependent Effects Of Celecoxibe On Model Membranes

Celecoxib is a new generation non-steroidal anti- inflammatory drug that selectively inhibits cyclooxygenase-2 and has reduced side effects because of its selectivity. Celecoxib has also been shown to have anti-cancer activity in several cancer types but its action of mechanism is not well understood. Since biological membranes are extremely complex structures, studying the effects of drugs on simple model membranes would be a convenient way to investigate drug-membrane interactions. Fourier Transform Infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC) and turbidity are three non-invasive techniques that give information about the structure, thermotropic phase behavior and dynamics of the membranes. The purpose of the study is to investigate the effects of celecoxib on 1,2-Distearoyl-sn-Glycero- 3-Phosphocholine (DSPC) model membranes as a function of temperature and celecoxib concentration, using FTIR spectroscopy, DSC and turbidity at 440 nm, thereby gain information about the interaction of this drug with biological membranes. This would also help us to understand the action mechanisms of celecoxib other than COX-2 inhibition.