Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Functional Application Of İmmununoliposomes Encapsulating Celecoxib On Colon Cancer Cell Lines.
Date
2010-12-31
Author
Banerjee, Sreeparna
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
372
views
0
downloads
Cite This
Long term regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been correlated with reduced risk of variety of cancers. Celecoxib is a new generation NSAID that can selectively inhibit activity of cyclooxygenase-2 (COX-2) Celecoxib serves as a chemopreventive agent in colorectal cancer. Therefore there is growing interest in developing drug delivery systems for celecoxib, Targeting will be carried out by conjugation of a chimeric monoclonal antibody (Cetuximab) against the Epidermal Growth Factor Receptor (EGFR). EGFR, which binds to epidermal growth factor, is essential in the normal maintenance of cellular growth and function. However, the receptor is known to be dysregulated in 25-77% of colorectal cancers and 85% of metastatic colorectal cancers. In this project we propose to prepare PEGylated liposomes encapsulating celecoxib, which will be converted immunoliposomes by conjugating to an anti-EGFR antibody. The combined inhibition of COX-2 by celecoxib and EGFR by cetuximab has been previously shown to synergistically reduce the metastatic potential of breast cancer in in vivo models (Gupta et al., 2007). Preliminary studies carried out in our laboratory indicate successful liposomal encapsulation and release of celecoxib (Deniz, Sade, Severcan, Keskin, Tezcaner & Banerjee, 2009). We therefore propose that the immunoliposomal preparation for the targeted delivery of celecoxib may hold promise for future therapeutic opportunities in colon cancer.
URI
https://hdl.handle.net/11511/59835
Collections
Graduate School of Natural and Applied Sciences, Project and Design
Suggestions
OpenMETU
Core
Investigation Of Nsaıd Lipid İnteractions Membranes Via Spectroscopic And Themoanalytical Techniques.
Banerjee, Sreeparna(2011-12-31)
Long term regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been correlated with reduced risk of variety of cancers. Celecoxib is a new generation NSAID that can selectively inhibit activity of cyclooxygenase-2 (COX-2) enzyme in prostaglandin production pathway The anticarcinogenic effects of Celecoxib are not solely due to the inhibition of COX-2. COX-2 independent effects observed in vitro can be summarized as inhibition of cell cycle progression, induction of apoptosis, and inhibition of ...
Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery
Tansik, Gulistan; YAKAR, ARZU; Gündüz, Ufuk (2013-12-07)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells, which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale-based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an exter...
Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer
Nezir, Ayca Ece; PARLAK KHALİLY, MELEK; Gulyuz, Sevgi; Özçubukçu, Salih; KÜÇÜKGÜZEL, ŞÜKRİYE GÜNİZ; Yilmaz, Ozgur; TELCİ, DİLEK (2021-04-01)
High toxicity caused by chemotherapeutic drugs and the acquisition of drug resistance by cancer cells are the major drawbacks in cancer therapy. A promising approach to overcome the posed barriers is conjugating tumor-homing peptides to drugs or nanocarriers. Such high-affinity peptides can specifically target surface markers overexpressed by cancer cells, ensuring a rapid and cancer-specific uptake of the drugs. Since prostate-specific membrane antigen (PSMA) is overexpressed by aggressive prostate cancer ...
Structural effects of simvastatin on liver rate tissue: Fourier transform infrared and Raman microspectroscopic studies
Garip, Sebnem; Bayari, Sevgi Haman; Severcan, Mete; Abbas, Sherif; Lednev, Igor K.; Severcan, Feride (2016-02-01)
Simvastatin is one of the most frequently prescribed statins because of its efficacy in the treatment of hypercholesterolemia, reducing cardiovascular risk and related mortality. Determination of its side effects on different tissues is mandatory to improve safe use of this drug. In the present study, the effects of simvastatin on molecular composition and structure of healthy rat livers were investigated by Fourier transform infrared and Raman imaging. Simvastatin-treated groups received 50 mg/kg/day simva...
Synthesis of poly (dl-lactic-co-glycolic acid) coated magnetic nanoparticles for anti-cancer drug delivery
Tansık, Gülistan; Gündüz, Ufuk; Department of Biology (2012)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an extern...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
S. Banerjee, “Functional Application Of İmmununoliposomes Encapsulating Celecoxib On Colon Cancer Cell Lines.,” 2010. Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/59835.