Highly efficient and selective olefination of acyl phosphonates with ethyl diazoacetate catalyzed by a cobalt(II) porphyrin complex

Date

2008-08-04

Author

Erturk, Erkan
Demir, Ayhan Sıtkı

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The cobalt(II) porphyrin complex (CoTPP) was found to be an efficient catalyst for the Wittig type olefination of acyl phosphonates with ethyl diazoacetate (EDA) in the presence of triphenylphosphine (Ph(3)P). By using this one pot methodology under mild conditions, densely functionalized vinyl phosphonates were obtained in high yields and high E/Z selectivities in relatively short reaction times. A rather broad substrate spectrum and steric influence on the reaction rate were observed.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/62649

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2008.05.108

Collections

Department of Chemistry, Article

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Citation Formats

E. Erturk and A. S. Demir, “Highly efficient and selective olefination of acyl phosphonates with ethyl diazoacetate catalyzed by a cobalt(II) porphyrin complex,” TETRAHEDRON, pp. 7555–7560, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/62649.