Feedback controlled electrical nerve stimulation: A computer simulation

Date

2010-07-01

Author

Doruk, R. Ozgur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

172
views

0
downloads

The role of repetitive firing in neurophysiologic or neuropsychiatric disorders, such as Parkinson, epilepsy and bipolar type disorders, has always been a topic of medical research as therapies target either the cease of firing or a decrease in its frequency. In electrotherapy, one of the mechanisms to achieve the purpose in point is to apply a low density electric current to the nervous system. In this study, a computer simulation is provided of a treatment in which the stimulation current is computed by nerve fiber cell membrane potential feedback so that the level of the current is automatically instead of manually adjusted. The behavior of the nerve cell is represented by the Hodgkin-Huxley (HH) model, which is slightly modified into a linear model with state dependent coefficients. Due to this modification, the algebraic and differential Riccati equations can be applied, which allows an optimal controller minimizing a quadratic performance index given by the user. Using a controlled current injection can decrease unnecessarily long current injection times that may be harmful to the neuronal network. This study introduces a prototype for a possible future application to a network of neurons as it is more realistic than a single neuron. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Subject Keywords

Software, Health Informatics, Computer Science Applications

URI

https://hdl.handle.net/11511/63980

Journal

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

DOI

https://doi.org/10.1016/j.cmpb.2010.01.006

Collections

Engineering, Article

Suggestions

OpenMETU
Core

Not just data: A method for improving prediction with knowledge Yet, Barbaros; Fenton, Norman; Tai, Nigel; Marsh, William (Elsevier BV, 2014-04-01) Many medical conditions are only indirectly observed through symptoms and tests. Developing predictive models for such conditions is challenging since they can be thought of as 'latent' variables. They are not present in the data and often get confused with measurements. As a result, building a model that fits data well is not the same as making a prediction that is useful for decision makers. In this paper, we present a methodology for developing Bayesian network (BN) models that predict and reason with la...
Preliminary results of a novel enhancement method for high-frequency hearing loss Arioz, Umut; Arda, Kemal; Tuncel, Umit (Elsevier BV, 2011-06-01) In this study, a software program was developed for high-frequency hearing loss subjects that includes a detailed audiogram and novel enhancement methods. The software performs enhancements of the audibility of high-frequency sounds according to the subject's detailed 31-point audiogram. This provides subject-specific gains in the entire frequency spectrum, and especially for high frequencies, of sounds. Amplification, compression, and transposition are the three main processing methods used to obtain the d...
Development of a computer algorithm for feedback controlled electrical nerve fiber stimulation Doruk, R. Ozgur (Elsevier BV, 2011-09-01) The purpose of this research is to develop an algorithm for a feedback controlled local electrical nerve fiber stimulation system which has the purpose to stop the repetitive firing in a particular region of the nervous system. The electrophysiological behavior of the neurons (under electrical currents) is modeled by Hodgkin-Huxley (HH) type nonlinear nerve fiber dynamics. The repetitive firing of in the modeled fiber is due to the deviations in the channel parameters, which is also called as bifurcation in...
Epileptic seizures induce structural and functional alterations on brain tissue membranes Turker, Sevgi; Severcan, Mete; İLBAY, GÜL; Severcan, Feride (2014-12-01) Epilepsy is characterized by disruption of balance between cerebral excitation and inhibition, leading to recurrent and unprovoked convulsions. Studies are still underway to understand mechanisms lying epileptic seizures with the aim of improving treatment strategies. In this context, the research on brain tissue membranes gains importance for generation of epileptic activities. In order to provide additional information for this field, we have investigated the effects of pentylenetetrazol-induced and audio...
Perceived parenting styles, emotion recognition, and emotion regulation in relation to psychological well-being : symptoms of depression, obsessive-compulsive disorder, and social anxiety Aka, B. Türküler; Gençöz, Tülin; Department of Psychology (2011) The purpose of the current study was to examine the path of perceived parenting styles, emotion recognition, emotion regulation, and psychological well-being in terms of depression, obsessive-compulsive disorder and social anxiety symptoms consequently. For the purpose of this study 530 adults (402 female, 128 male) between the ages of 18 and 36 (M = 22.09, SD = 2.78) participated in the current study. The data was collected by a questionnaire battery including a Demographic Category Sheet, Short-EMBU (Egna...

Citation Formats

R. O. Doruk, “Feedback controlled electrical nerve stimulation: A computer simulation,” COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, pp. 98–112, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/63980.