Diagnostic Criteria And Clinical Manifestations Of Presumed Latent Tuberculosis-Related Uveitis In A Bacille Calmette-Guerin Vaccinatinated Community

Gurses, Ozlem
Karaismailoglu, Eda
Purpose: The wide range of clinical manifestations of presumed latent tuberculosis-related uveitis (TRU) make its diagnosis difficult in an endemic community. We described the ocular manifestations of patients with TRU, and we evaluated the correlation between skin induration value of tuberculin skin test (TST) and tuberculosis antigens tube value of QuantiFERON®-TB Gold (QFT) test in a Bacille Calmette-Guerin<br /> (BCG) vaccinated community. Methods: This was a prospective 1-year study in a tertiary referral center. 85 patients,47 (55.3 %) female diagnosed with TRU were included. Mean (standard deviation, SD) age was 52.9 (13.6) years. TST, QFT and pulmonary X-ray were performed. Other possible etiologies of uveitis were ruled-out. Standard anti-tuberculosis therapy (ATT) was started, and response to ATT was monitored. Statistical analysis was performed by<br /> using SPSS for Windows 13.0.1 (SPSS Inc., Chicago, IL, USA) Pearson correlation coefficient (r) was used for analysis. p < 0.05 was considered as significant.<br /> Results: 43 patients (50.6%) had bilateral involvement. The most common ocular manifestation was anterior uveitis (78.8 %) followed by vitritis, panuveitis, papillitis, vasculitis, chorioretinitis and scleritis. The mean (SD) value of TST was 16.53 (6.05) mm and the mean (SD) value of QFT was 8.06 (4.53) IU/ml. Pulmonary X-ray results were normal. All the patients responded to ATT. No statistically significant correlation was found between TST and QFT. (r= 0.105, p=0.498)<br /> Conclusions: There is no pathognomonic clinical manifestation of TRU in an endemic, BCG vaccinated community. Presence of bilateral anterior uveitis, positive results for both TST and QFT, and positive response to ATT support the diagnosis of TRU in an endemic, BCG vaccinated community.


Variations Of Choroidal And Retinal Thickness Measurements Analyzed By Enhanced Depth Imaging Optical Coherence Tomography In Uveitis
Gurses, Ozlem; Karaismailoglu, Eda (2016-09-01)
Purpose : Choroidal thickness (CT) is considered a promising parameter to monitor the severity of inflammation. We hypothesize that inflammation of the iris and ciliary body in anterior uveitis might affect the CT, and inflammation of the choroid in intermediate, posterior and panuveitis might affect the retinal thickness.(RT) Methods : Prospective case-control study of 32 eyes with anterior, 5 eyes with intermediate, 24 eyes with posterior, 24 eyes with panuveitis, and 51 control eyes were performed with ...
Diagnostic prediction model development using data from dried blood spot proteomics and a digital mental health assessment to identify major depressive disorder among individuals presenting with low mood.
Han, SYS; Tomasik, J; Rustogi, N; Lago, SG; Barton-Owen, G; Eljasz, P; Cooper, JD; Özcan Kabasakal, Süreyya; Olmert, T; Farrag, LP; Friend, LV; Bell, E; Cowell, D; Thomas, G; Tuytten, R; Bahn, S (Elsevier BV, 2020-11-01)
With less than half of patients with major depressive disorder (MDD) correctly diagnosed within the primary care setting, there is a clinical need to develop an objective and readily accessible test to enable earlier and more accurate diagnosis. The aim of this study was to develop diagnostic prediction models to identify MDD patients among individuals presenting with subclinical low mood, based on data from dried blood spot (DBS) proteomics (194 peptides representing 115 proteins) and a novel digital menta...
Investigation of schizophrenia related genes and pathways through genome wide association studies
Döm, Hüseyin Alper; Aydın Son, Yeşim; Department of Bioinformatics (2013)
Schizophrenia is a complex mental disorder that is commonly characterized as deterioration of intellectual process and emotional responses and affects 1% of any given population. SNPs are single nucleotide changes that take place in DNA sequences and establish the major percentage of genomic variations. In this study, our goal was to identify SNPs as genomic markers that are related with schizophrenia and investigate the genes and pathways that are identified through the analysis of SNPs. Genome wide associ...
Ophthalmoparesis, papillitis and premacular hemorrhage in a case with endocarditis: A rare presentation ofBrucellosis
Sahin, OzlemGurses; Pelit, Aysel; Turunc, Tugba; Akova, YoncaAydln (Medknow, 2010)
We report a rare presentation of brucellosis as bilateral optic nerve and right abducent nerve involvement, and endocarditis complicated by right premacular hemorrhage in a 28-year-old white female. The patient showed improvement with both medical and surgical therapy. Brucellosis should be considered in the differential diagnosis of papillitis, gaze palsy and endocarditis complicated with premacular hemorrhage in endemic regions.
Impact of Iontophoresis and PACK-CXL Corneal Concentrations of Antifungals in an In Vivo Model
KALKANCI, AYŞE; Yesilirmak, Nilufer; Ozdemir, Huseyin Baran; Unal, Elif Ayca; Erdogan, Merve; Şeker, Tamay; Tum, Atakan Emre; Karakus, Ahmet Kamil; Hizel, Kenan; Bilgihan, Kamil (Ovid Technologies (Wolters Kluwer Health), 2018-11-01)
Purpose: To investigate voriconazole (VRZ) penetration and fungal load in the cornea after applying VRZ therapy with various treatment combinations in a fungal keratitis model. Methods: Fifty-four eyes of 27 young albino rabbits were provided for this experimental study. Twelve corneas were inoculated with Candida albicans, 12 corneas were inoculated with Fusarium solani, and 6 eyes were selected as controls. Infected corneas received various treatment combinations including VRZ 1% drop therapy alone, VRZ 1...
Citation Formats
O. Gurses and E. Karaismailoglu, “Diagnostic Criteria And Clinical Manifestations Of Presumed Latent Tuberculosis-Related Uveitis In A Bacille Calmette-Guerin Vaccinatinated Community,” 2015, vol. 56, p. 0, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/65298.