Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4

Date

2013-03-01

Author

Celik, Haydar
Arinc, Emel

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1. This study attempted to investigate the ability of microsomal NADH-cytochrome b5 reductase and cytochrome P450 2B4 to reductively activate idarubicin and mitomycin C.

Subject Keywords

Quinone antitumor agents, Purified enzymes, Plasmid DNA damage, One-electron reduction, Reconstituted systems

URI

https://hdl.handle.net/11511/65730

Journal

XENOBIOTICA

DOI

https://doi.org/10.3109/00498254.2012.715212

Collections

Department of Biology, Article

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Citation Formats

H. Celik and E. Arinc, “Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH-cytochrome b5 reductase and cytochrome P450 2B4,” XENOBIOTICA, pp. 263–275, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/65730.