Silver nanoparticles-tragacanth gel as a green membrane for effective extraction and determination of capecitabine

Date

2020-07-01

Author

Hajizadeh, Salahaddin
Farhadi, Khalil
Molaei, Rahim
Forough, Mehrdad

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

208
views

0
downloads

A novel eco-friendly and effective electromembrane extraction method combining high-performance liquid chromatography with UV detection was developed for the enrichment and determination of capecitabine. Tragacanth-silver nanoparticles conjugated gel was prepared by dissolving the tragacanth powder in synthesized silver nanoparticles solution and was used as a green membrane in electromembrane extraction. The porosity and presence of silver nanoparticles in the gel were characterized by field emission scanning electron microscopy. This new electromembrane extraction approach uses neither organic solvent nor carrier agents to extract the target analyte. The best electromembrane extraction efficiency was obtained by using 4.0 mm membrane gel thickness containing 2.5% w/v of tragacanth gum, donor phase pH = 5.0, acceptor phase pH = 3.0, applied voltage 50 V, extraction time 20 min, and agitation rate 500 rpm. During method validation under the optimized conditions, good linearity dynamic range between 1 and 500 ng/mL with the coefficient of determination (R-2) = 0.998 was obtained. Limit of detection and Limit of quantitation were estimated to be 0.84 and 1.0 ng/mL, respectively. Finally, the applicability of this method in real samples was confirmed by an acceptable performance in extraction and determination of capecitabine in human plasma samples.

Subject Keywords

Filtration and Separation, Analytical Chemistry

URI

https://hdl.handle.net/11511/67463

Journal

JOURNAL OF SEPARATION SCIENCE

DOI

https://doi.org/10.1002/jssc.202000251

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

Removal of hexavalent chromium anions via polymer enhanced ultrafiltration using a fully ionized polyelectrolyte HAKTANIR, CEREN; Ozbelge, H. Onder; Bicak, Niyazi; Yılmaz, Levent (Informa UK Limited, 2017-01-01) A fully ionized polyelectrolyte was synthesized for Cr(VI) removal from aqueous solutions by continuous polymer enhanced ultrafiltration (PEUF). Effect of operating parameters such as pH, loading, polymer, and competing ion concentrations were examined. Highest Cr(VI) retention was obtained at a loading of 0.01 at pH 4. Increasing both polymer and chromate concentrations at a fixed loading of 0.01 decreased the retention which demonstrated the effect of crowding. In the presence of competing anions such as ...
Nanofiltration and Reverse Osmosis for Reuse of Indigo Dye Rinsing Waters Uzal, Nigmet; Yılmaz, Levent; Yetiş, Ülkü (Informa UK Limited, 2010-01-01) A membrane based treatment strategy was developed for the possible recycling of rinsing wastewater from indigo dyeing to the process itself. Performances of three different nanofiltration (NF) (NF 270 and NF 90, Dow Film Tech, USA and NF 99, Alfa Laval, Denmark) and two different reverse osmosis (RO) (HR 98 PP and CA 995 PE, Alfa Laval, Denmark) membranes were investigated with wastewater collected from the first post-rinsing tank of indigo dyeing process of a denim manufacturing plant. Dead-end microfiltra...
Determination of silver by chemical vapour generation and atomic absoption spectrometry Öztürk, Çağla Pınar; Ataman, Osman Yavuz; Department of Chemistry (2004) A method for determination of silver has been developed based on chemical vapour generation atomic absorption spectrometry (CVGAAS). Volatile species of silver in acidified medium were generated by the reduction of sodium tetrahydroborate; these species were sent to a flame-heated quartz tube atomizer (QTA) following isolation by using a gas-liquid separator. Flow injection (FI) was used for sample introduction. Optimization of parameters such as; concentrations of acid and NaBH4 concentration, flow rates o...
Hydrogen sulfide determination by solid surface luminescence Eroglu, AE; Volkan, Mürvet; Bayramh, E; Ataman, Osman Yavuz; Mark, HB (1996-07-01) In the analytical system suggested, atmospheric hydrogen sulfide reacts with the surface of a filter paper treated with aqueous cadmium chloride and yields a luminescent species whose intensity can be correlated with the analyte concentration in ambient air. It was shown that the luminescent species are CdS solid particles which were formed in a well defined size. The paper luminescence was also tried on polymeric surfaces; polyethyleneoxide, polyvinyl alcohol, ethylcellulose and carboxymethylcellulose were...
Eriochrome Black T-Eu3+ Complex as a Ratiometric Colorimetric and Fluorescent Probe for the Detection of Dipicolinic Acid, a Biomarker of Bacterial Spores Yilmaz, M. Deniz; Öktem, Hüseyin Avni (American Chemical Society (ACS), 2018-03-20) A novel ratiometric colorimetric and fluorescent dual probe based on Eriochrome Black T (EBT) Eu3+ complex was designed to detect dipicolinic acid (DPA), a major constituent of bacterial spores, with high sensitivity and selectivity. UV vis titration experiments demonstrated that EBT and Eu3+ ions formed a 1:1 coordination pair in water. In the presence of Eu3+ ions, the blue solution of EBT changed to magenta, however, upon the addition of DPA, the magenta color changed to blue immediately and characterist...

Citation Formats

S. Hajizadeh, K. Farhadi, R. Molaei, and M. Forough, “Silver nanoparticles-tragacanth gel as a green membrane for effective extraction and determination of capecitabine,” JOURNAL OF SEPARATION SCIENCE, pp. 2666–2674, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/67463.