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Reduction of surgery-induced peritoneal adhesions by continuous release of streptokinase from a drug delivery system
Date
2003-01-01
Author
Yagmurlu, A
Barlas, M
Gursel, I
Gokcora, IH
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Postoperative abdominal adhesions may lead to intestinal obstruction and infertility. The effect of continuous release of streptokinase to the peritoneal cavity on postoperative adhesions was examined under experimental conditions. Peritoneal adhesions were induced in rats and the animals were further treated by intraperitoneal administration of streptokinase solution, polyhydroxy-butyrate-co-hydroxyvalerate (PHBV) membrane alone and streptokinase loaded PHBV membrane and compared to sham operated and untreated groups. Formation of adhesions was evaluated by quantitative macroscopic grading, histopathologically with light microscopy, on the following week. Streptokinase loaded PHBV prevented postoperative adhesion formation in 90% of the cases. PHBV membrane alone also reduced the severity of adhesions due to its anti-adhesive properties. Histopathological examination revealed limited foreign body reaction due to PHBV. Continuous streptokinase activity in the peritoneal cavity during early post-surgical period prevents postoperative adhesion. Copyright (C) 2003 S. Karger AG, Basel.
Subject Keywords
Surgery
URI
https://hdl.handle.net/11511/67615
Journal
EUROPEAN SURGICAL RESEARCH
DOI
https://doi.org/10.1159/000067035
Collections
Biomaterials and Tissue Engineering Application and Research Center (BİOMATEN), Article