Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles

Date

2017-03-01

Author

ALTAY, AHMET
CELEP, ADVİYE GÜLÇİN SAĞDIÇOĞLU
YAPRAK, AHMET EMRE
BAŞKÖSE, İSA
Bozoglu, Faruk

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In this study, the possible uses of glassworts as potential food ingredients and their antiproliferative activity against colorectal adenocarcinoma cells together with their antioxidant and phytochemical profiles were investigated for the first time. MeOH extracts of five different taxa collected from different localities were screened for their antioxidant capacities by DPPH (IC50 2.91-5.49mg/ml) and ABTS (24.4-38.5molTE/gextract) assays. Salicornia freitagii exhibited the highest DPPH radical scavenging activity. LC/MS/MS analysis displayed that vanillic acid and p-coumaric acid were two main phenolic compounds in the extract. Salicorniafreitagii extracts also exhibited high antiproliferative activity against HT-29 (IC50 1.67mg/ml) and Caco-2 (IC50 3.03mg/ml) cells for 72h. Mineral analysis indicated that all the species with different proportions of elemental components contained high amount of cations. These results indicate that investigated glassworts, with their high phenolic and mineral contents and also notable antioxidant and cytotoxic properties, may be utilized as a promising source of therapeutics.

Subject Keywords

Glassworts, Antioxidants, Cytotoxicity, Colon Cancer, Minerals

URI

https://hdl.handle.net/11511/68135

Journal

CHEMISTRY & BIODIVERSITY

DOI

https://doi.org/10.1002/cbdv.201600290

Collections

Department of Food Engineering, Article

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Citation Formats

A. ALTAY, A. G. S. CELEP, A. E. YAPRAK, İ. BAŞKÖSE, and F. Bozoglu, “Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles,” CHEMISTRY & BIODIVERSITY, pp. 0–0, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68135.