Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles
Date
2017-03-01
Author
ALTAY, AHMET
CELEP, ADVİYE GÜLÇİN SAĞDIÇOĞLU
YAPRAK, AHMET EMRE
BAŞKÖSE, İSA
Bozoglu, Faruk
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
196
views
0
downloads
Cite This
In this study, the possible uses of glassworts as potential food ingredients and their antiproliferative activity against colorectal adenocarcinoma cells together with their antioxidant and phytochemical profiles were investigated for the first time. MeOH extracts of five different taxa collected from different localities were screened for their antioxidant capacities by DPPH (IC50 2.91-5.49mg/ml) and ABTS (24.4-38.5molTE/gextract) assays. Salicornia freitagii exhibited the highest DPPH radical scavenging activity. LC/MS/MS analysis displayed that vanillic acid and p-coumaric acid were two main phenolic compounds in the extract. Salicorniafreitagii extracts also exhibited high antiproliferative activity against HT-29 (IC50 1.67mg/ml) and Caco-2 (IC50 3.03mg/ml) cells for 72h. Mineral analysis indicated that all the species with different proportions of elemental components contained high amount of cations. These results indicate that investigated glassworts, with their high phenolic and mineral contents and also notable antioxidant and cytotoxic properties, may be utilized as a promising source of therapeutics.
Subject Keywords
Glassworts
,
Antioxidants
,
Cytotoxicity
,
Colon Cancer
,
Minerals
URI
https://hdl.handle.net/11511/68135
Journal
CHEMISTRY & BIODIVERSITY
DOI
https://doi.org/10.1002/cbdv.201600290
Collections
Department of Food Engineering, Article
Suggestions
OpenMETU
Core
Modulation of mRNA expression and activities of xenobiotic metabolizing enzymes, CYP1A1, CYP1A2, CYP2E1, GPx and GSTP1 by the Salicornia freitagii extract in HT-29 human colon cancer cells
ALTAY, AHMET; İrtem Kartal, Deniz; SADİ, GÖKHAN; Güray, Nülüfer Tülün; YAPRAK, AHMET EMRE (2017-01-01)
Phase I-II detoxification and antioxidant enzymes are responsible for the detoxification and elimination of activated carcinogens, acting as important biomarkers for chemoprevention. Among them, cytochrome P450s plays a prominent role in the metabolic activation of xenobiotics. The herb Salicornia freitagii (SF) (Amaranthaceae) is known for its anticancer, antioxidant, antidiabetic and antiinflammatory activities. In this study, we determined the bioactive phenolics in the SF methanol extract and investigat...
ANTIOXIDANT RESPONSES OF PEANUT (ARACHIS HYPOGAEA L.) SEEDLINGS TO PROLONGED SALT-INDUCED STRESS
KAVAS, MUSA; Akca, Oya Ercan; Akcay, Ufuk Celikkol; Peksel, Begum; Eroğlu, Seçkin; Öktem, Hüseyin Avni; Yucel, Meral (2015-01-01)
In this study, the effects of long-term NaCl treatment were investigated in two cultivars of peanut designated as drought-resistant and drought-sensitive. Growth parameters, changes in the concentrations of MDA, H2O2 and proline, and the activities of antioxidant enzymes were determined under salinity stress. Growth parameters indicated the superiority of cv. Florispan to cv. Gazipasa under milder salinity stress treatment. However, comparative analysis of the two cultivars showed that MDA, H2O2, ion leakag...
Microencapsulation of phenolic compounds extracted from onion (Allium cepa) skin
AKDENIZ, Busra; Şümnü, Servet Gülüm; Şahin, Serpil (2018-07-01)
The objective of this study was to investigate the effect of different coating materials for encapsulation of phenolic compounds extracted from onion skin. As coating material, maltodextrin (MD) was combined with gum Arabic (GA), casein, or whey protein concentrate (WPC) at different ratios (8:2 and 6:4). Encapsulation efficiency, antioxidant activity, particle size distribution, and heat stability were analyzed in freeze dried microcapsules. The encapsulation efficiency values were found to be highest with...
Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties
SADİ, GÖKHAN; KAYA, ABDULLAH; Yalcin, Hicret Asli; EMSEN, BUĞRAHAN; KOCABAŞ, AYTAÇ; Kartal, Deniz Irtem; Altay, Ahmet (2016-01-01)
This study was designed to reveal cell growth inhibitory potential of six different edible mushrooms: Ramaria flava, Agrocybe molesta, Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and Tricholoma terreum on HepG2 cells together with their antioxidant and antibacterial power. Methanolic extracts of V. gloiocephalus and aqueous extracts of R. flava had the most potential cytotoxic effects over HepG2 cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities we...
Photobiological hydrogen production from sugar beet molasses
Sağır, Emrah; Yücel, Ayşe Meral; Özgür, Ebru; Department of Biochemistry (2012)
The main aim of this study was to investigate biological hydrogen production from sucrose and molasses by purple non-sulphur bacteria (PNS). The hydrogen production capacities of four different PNS bacteria (Rhodobacter capsulatus (DSM 1710), Rhodobacter capsulatus YO3 (Hup-), Rhodopseudomonas palustris (DSM 127) and Rhodobacter sphaeroides O.U.001 (DSM 5864)) were tested on sucrose and molasses. The photobiological hydrogen production were performed in 50 ml and 150 ml small scale photobioreactors, in batc...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
A. ALTAY, A. G. S. CELEP, A. E. YAPRAK, İ. BAŞKÖSE, and F. Bozoglu, “Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles,”
CHEMISTRY & BIODIVERSITY
, pp. 0–0, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68135.