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Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties
Date
2016-01-01
Author
SADİ, GÖKHAN
KAYA, ABDULLAH
Yalcin, Hicret Asli
EMSEN, BUĞRAHAN
KOCABAŞ, AYTAÇ
Kartal, Deniz Irtem
Altay, Ahmet
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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This study was designed to reveal cell growth inhibitory potential of six different edible mushrooms: Ramaria flava, Agrocybe molesta, Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and Tricholoma terreum on HepG2 cells together with their antioxidant and antibacterial power. Methanolic extracts of V. gloiocephalus and aqueous extracts of R. flava had the most potential cytotoxic effects over HepG2 cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities were obtained from both aqueous and methanolic extracts of R. flava. Methanolic extracts of T. terreum (IC50 = 1.62 mg/mL) and aqueous extracts of B. plumbea (IC50 = 0.49 mg/mL) showed maximum metal chelating activity. The highest reducing capacities were observed among the methanolic extracts of R. flava (EC50 = 1.65 mg/mL) and aqueous extracts of B. plumbea (EC50 = 1.71 mg/mL). High-performance liquid chromatography analysis revealed the presence of many phenolic compounds in macrofungi; gallic acid and p-coumaric acid were the two main phenolics identified in all extracts. Antibacterial studies indicated that all six tested mushrooms showed antibacterial activity on at least three microorganisms. These results indicate that different extracts of the investigated mushrooms have considerable cytotoxic, antioxidant, and antibacterial properties and may be utilized as a promising source of therapeutics.
Subject Keywords
Medicinal and edible mushrooms
,
HepG2
,
Cytotoxicity
,
Antibacterial effect
,
Antioxidants
URI
https://hdl.handle.net/11511/68398
Journal
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
DOI
https://doi.org/10.1615/intjmedmushrooms.v18.i1.100
Collections
Graduate School of Natural and Applied Sciences, Article
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G. SADİ et al., “Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties,”
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
, pp. 83–95, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68398.