Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties

2016-01-01
SADİ, GÖKHAN
KAYA, ABDULLAH
Yalcin, Hicret Asli
EMSEN, BUĞRAHAN
KOCABAŞ, AYTAÇ
Kartal, Deniz Irtem
Altay, Ahmet
Show full item record
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
174
views
0
downloads
This study was designed to reveal cell growth inhibitory potential of six different edible mushrooms: Ramaria flava, Agrocybe molesta, Volvopluteus gloiocephalus, Lactarius deliciosus, Bovista plumbea, and Tricholoma terreum on HepG2 cells together with their antioxidant and antibacterial power. Methanolic extracts of V. gloiocephalus and aqueous extracts of R. flava had the most potential cytotoxic effects over HepG2 cells. The best results for 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities were obtained from both aqueous and methanolic extracts of R. flava. Methanolic extracts of T. terreum (IC50 = 1.62 mg/mL) and aqueous extracts of B. plumbea (IC50 = 0.49 mg/mL) showed maximum metal chelating activity. The highest reducing capacities were observed among the methanolic extracts of R. flava (EC50 = 1.65 mg/mL) and aqueous extracts of B. plumbea (EC50 = 1.71 mg/mL). High-performance liquid chromatography analysis revealed the presence of many phenolic compounds in macrofungi; gallic acid and p-coumaric acid were the two main phenolics identified in all extracts. Antibacterial studies indicated that all six tested mushrooms showed antibacterial activity on at least three microorganisms. These results indicate that different extracts of the investigated mushrooms have considerable cytotoxic, antioxidant, and antibacterial properties and may be utilized as a promising source of therapeutics.
Medicinal and edible mushrooms, HepG2, Cytotoxicity, Antibacterial effect, Antioxidants
https://hdl.handle.net/11511/68398
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
Graduate School of Natural and Applied Sciences, Article

Suggestions

Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles
ALTAY, AHMET; CELEP, ADVİYE GÜLÇİN SAĞDIÇOĞLU; YAPRAK, AHMET EMRE; BAŞKÖSE, İSA; Bozoglu, Faruk (2017-03-01)
In this study, the possible uses of glassworts as potential food ingredients and their antiproliferative activity against colorectal adenocarcinoma cells together with their antioxidant and phytochemical profiles were investigated for the first time. MeOH extracts of five different taxa collected from different localities were screened for their antioxidant capacities by DPPH (IC50 2.91-5.49mg/ml) and ABTS (24.4-38.5molTE/gextract) assays. Salicornia freitagii exhibited the highest DPPH radical scavenging a...
EVALUATION OF IN VIVO EFFECTS OF VISCUM ALBUM L. AND ITS CONSTITUENT O-COUMARIC ACID ON BILE ACID SYNTHESIZING CYPS
Ege, Tuba; Ozkan, Ayse Mine Gencler; Sena, Alaattin; Adalı, Orhan (2019-01-01)
This research was designed to determine about the possible potency of medicinal plants Viscum album L. and its major polyphenolic ingredient, o-coumaric acid on rat liver cholesterol and bile acid metabolizing enzymes. Bioactive compounds of V. album extracts were identified using LC-MS technique. The water extracts of V. album (10 mg/kg) and o-coumaric acid (30 mg/kg) were injected intraperitoneally for 9 days. Then, in vivo effects of this plant and its major phenolic ingredient (o-coumaric acid) on rat l...
The role of the cross pathway control protein in the stress response and adaptation of aspergillus species to antifungals
Amarsaikhan, Nansalmaa; Ögel, Zümrüt Begüm; Bakır, Ufuk; Department of Biotechnology (2010)
In this study, the adaptation and response of Aspergillus nidulans and Aspergillus fumigatus wild type and cpcA strains to antifungal compounds were studied using cultural, genetic and proteomic methods. CpcA is the fungal cross pathway control protein which may also have a role in the development of resistance to antifungal that has become a major problem in human and plant fungal diseases and many studies are devoted to address the drug resistance mechanisms. Cell adapts itself to stress when it is subje...
Antibacterial Effect of Silver-Zeolite Containing Root-Canal Filling Material
ÇINAR, ÇAĞDAŞ; Ulusu, Tezer; ÖZÇELİK, BERRİN; Karamuftuoglu, Nevra; Yücel, Hayrettin (2009-08-01)
The aim of this study was to determine the in vitro antibacterial effect of two experimental glass ionomer cements (GICs) on Streptococcus milleri, Staphylococcus aureus, and Enterococcus faecalis after 24 and 48 h incubation by using the agar diffusion inhibitory test. Silver zeolite (SZ) was added at 0.2 and 2% mass fraction concentration to GIC (Endion). The control group was Endion with no SZ. Each of them were prepared to uniform size using a custom-made Teflon mold, and the GIC materials were prepared...
A Comparison on protein, bacterial anti-adhesive and anti-bacterial properties of zwitterionic block copolymer micelle containing ultra-thin films of varying compositions
Ulusan, Sinem; Erel Göktepe, İrem; Banerjee, Sreeparna; Department of Chemistry (2019)
In this study preparation of ultra-thin coatings of zwitterionic block copolymer micelles and a comparison of their protein adsorption, adhesiveness and anti-bacterial properties as well as adhesiveness against osteoblast-like cells were studied. Zwitterionic block copolymer micelles were obtained through pH-induced self-assembly of poly[3-dimethyl (methacryloyloxyethyl) ammonium propane sulfonate-b-2-(diisopropylamino)ethyl methacrylate] (βPDMA-b-PDPA) at pH 7.5. βPDMA-b-PDPA micelles with zwitterionic βPD...
Citation Formats
G. SADİ et al., “Wild Edible Mushrooms from Turkey as Possible Anticancer Agents on HepG2 Cells Together with Their Antioxidant and Antimicrobial Properties,” INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS, pp. 83–95, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/68398.
METU IIS - Integrated Information Service open@metu.edu.tr