Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes

Yao, Chen
Chen, Brian H.
Joehanes, Roby
Otlu, Burcak
Zhang, Xiaoling
Liu, Chunyu
Huan, Tianxiao
Tastan, Oznur
Cupples, L. Adrienne
Meigs, James B.
Fox, Caroline S.
Freedman, Jane E.
Courchesne, Paul
O'Donnell, Christopher J.
Munson, Peter J.
Keles, Sunduz
Levy, Daniel
Background-Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these variants in disease processes remains unknown.


Metabolic syndrome and its components among women with polycystic ovary syndrome: a systematic review and meta-analysis
Hallajzadeh, Jamal; Khoramdad, Maliheh; Karamzad, Nahid; Almasi-Hashiani, Amir; Janati, Ali; Ayubi, Erfan; Pakzad, Reza; Sullman, Mark J. M.; Safiri, Saeid (Maad Rayan Publishing Company, 2018-01-01)
Introduction: The objectives of this study were to provide an estimate of the prevalence of metabolic syndrome (MetS) and its components among women with PCOS; and calculate the odds ratio (OR) for MetS (using different definitions of MetS) in women with PCOS, compared to healthy controls.
Stepwise Reversal of Immune Dysregulation Due to STAT1 Gain-of-Function Mutation Following Ruxolitinib Bridge Therapy and Transplantation
Kayaoğlu, Başak; Yilmaz, Naz Surucu; Charbonnier, Louis Marie; Geckin, Busranur; Akcay, Arzu; Eltan, Sevgi Bilgic; Ozturk, Gulyuz; ÖZEN, AHMET OĞUZHAN; Karakoc-Aydiner, Elif; Chatila, Talal A.; Gürsel, Mayda (2021-01-01)
Purpose Patients with heterozygous gain-of-function (GOF) mutations in STAT1 frequently exhibit chronic mucocutaneous candidiasis (CMC), immunodeficiency and autoimmune manifestations. Several treatment options including targeted therapies and hematopoietic stem cell transplantation (HSCT) are available for STAT1 GOF patients but modalities and outcomes are not well established. Herein, we aimed to unravel the effect of ruxolitinib as a bridge therapy in a patient with sporadic STAT1 T385M mutation to manag...
Colicinogeny, lipopolysaccharide and outer membrane protein profiles of multi-drug resistant Salmonella typhimurium isolates from Turkey
İçgen, Bülent; Özcengiz, Gülay; Gültekin, Güzin Candan ( TÜBİTAK, 2002-01-01)
A total of 259 clinical isolates of non-repetitive non-typhi salmonellae (NTS) were previously examined for their antibiotic resistance patterns and plasmid contents. Multi-drug resistant strains comprised 19.3% (50/259) of the isolates and almost all were Salmonella typhimurium. In the present study, 35 of these multi-drug resistant S. typhimurium isolates were further characterized for colicinogeny, lipopolysaccharide (LPS) and outer membrane protein (OMP) profiles. Fourteen of the 35 (40%) isolates were ...
Anterior Mitral Leaflet Curvature During the Cardiac Cycle in the Normal Ovine Heart
Kvitting, JPE; Bothe, Wolfgang; Göktepe, Serdar; Rausch, Manuel; Swanson, Julia; Kuhl, Ellen; Ingels, Neil; Miller, Craig (Ovid Technologies (Wolters Kluwer Health), 2010-10-26)
Background-The dynamic changes of anterior mitral leaflet (AML) curvature are of primary importance for optimal left ventricular filling and emptying but are incompletely characterized.
Epigenetic Mechanisms Underlying the Dynamic Expression of Cancer-Testis Genes, PAGE2, -2B and SPANX-B, during Mesenchymal-to-Epithelial Transition
Yilmaz-Ozcan, Sinem; Sade, Asli; Kucukkaraduman, Baris; Kaygusuz, Yasemin; Senses, Kerem Mert; Banerjee, Sreeparna; GÜRE, ALİ OSMAY (Public Library of Science (PLoS), 2014-09-17)
Cancer-testis (CT) genes are expressed in various cancers but not in normal tissues other than in cells of the germline. Although DNA demethylation of promoter-proximal CpGs of CT genes is linked to their expression in cancer, the mechanisms leading to demethylation are unknown. To elucidate such mechanisms we chose to study the Caco-2 colorectal cancer cell line during the course of its spontaneous differentiation in vitro, as we found CT genes, in particular PAGE2, -2B and SPANX-B, to be up-regulated duri...
Citation Formats
C. Yao et al., “Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes,” CIRCULATION, pp. 536–746, 2015, Accessed: 00, 2020. [Online]. Available: