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Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes
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Date
2015-02-10
Author
Yao, Chen
Chen, Brian H.
Joehanes, Roby
Otlu, Burcak
Zhang, Xiaoling
Liu, Chunyu
Huan, Tianxiao
Tastan, Oznur
Cupples, L. Adrienne
Meigs, James B.
Fox, Caroline S.
Freedman, Jane E.
Courchesne, Paul
O'Donnell, Christopher J.
Munson, Peter J.
Keles, Sunduz
Levy, Daniel
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Background-Cardiovascular disease (CVD) reflects a highly coordinated complex of traits. Although genome-wide association studies have reported numerous single nucleotide polymorphisms (SNPs) to be associated with CVD, the role of most of these variants in disease processes remains unknown.
Subject Keywords
Physiology (medical)
,
Cardiology and Cardiovascular Medicine
URI
https://hdl.handle.net/11511/68612
Journal
CIRCULATION
DOI
https://doi.org/10.1161/circulationaha.114.010696
Collections
Department of Chemical Engineering, Article