Sequential treatment of HCC cells with PI3K Akt mTOR pathway inhibitors prior to sorafenib attenuates cancer stem cell population

Date

2016-07-01

Author

Kahraman, Deniz Cansen
Kahraman, Tamer
Atalay, Rengül

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

138
views

0
downloads

Subject Keywords

Cancer Research, Oncology

URI

https://hdl.handle.net/11511/69607

DOI

https://doi.org/10.1016/s0959-8049(16)61268-6

Collections

Graduate School of Informatics, Conference / Seminar

Suggestions

OpenMETU
Core

Serum Glycan Signatures of Gastric Cancer Özcan Kabasakal, Süreyya; Ruhaak, L. Renee; Torres, Javier; Cooke, Cara L.; An, Hyun Joo; Hua, Serenus; Williams, Cynthia C.; Dimapasoc, Lauren M.; Kim, Jae Han; Camorlinga-Ponce, Margarita; Rocke, David; Lebrilla, Carlito B.; Solnick, Jay V. (American Association for Cancer Research (AACR), 2014-02-01) Glycomics, a comprehensive study of glycans expressed in biologic systems, is emerging as a simple yet highly sensitive diagnostic tool for disease onset and progression. This study aimed to use glycomics to investigate glycan markers that would differentiate patients with gastric cancer from those with nonatrophic gastritis. Patients with duodenal ulcer were also included because they are thought to represent a biologically different response to infection with Helicobacter pylori, a bacterial infection tha...
Overexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells Erson Bensan, Ayşe Elif; DEMERS, SK; ROUILLARD, JM; HANASH, SM; PETTY, EM (Elsevier BV, 2001-11-01) 17q23 is a frequent site of gene amplification in breast cancer. Several lines of evidence suggest the presence of multiple amplicons on 17q23. To characterize distinct amplicons on 17q23 and localize putative oncogenes, we screened genes and expressed sequence tags (ESTs) in existing physical and radiation hybrid maps for amplification and overexpression in breast cancer cell lines by semiquantitative duplex PCR, semiquantitative duplex RT-PCR, Southern blot, and Northern blot analyses. We identified two d...
Tobacco, alcohol use, and risks of laryngeal and lung cancer by subsite and histologic type in Turkey Dosemeci, M; Gokmen, I; Unsal, H; Hayes, RB; Blair, A (Springer Science and Business Media LLC, 1997-09-01) Effects of tobacco smoking and alcohol use on risks of cancers of the larynx and lung have been evaluated extensively in industrialized countries, Few studies on the effect of these risk factors have been reported from developing countries. We conducted a case-control study to evaluate risks of laryngeal and lung cancers in men by subsite and cell type in relation to smoking and alcohol drinking in Turkey, a country where smoking and alcohol consumption patterns are different from those in industrialized co...
GST isoenzymes in matched normal and neoplastic breast tissue OĞUZTÜZÜN, SERPİL; Abu-Hijleh, A.; ÇOBAN, TÜLAY; Bulbul, D.; KILIÇ, MURAT; İŞCAN, Mümtaz; İşcan, Mesude (AEPress, s.r.o., 2011-01-01) The potential to metabolize endogenous and exogenous substances may influence breast cancer development and tumor growth. Therefore we investigated GST activity and the protein expression of glutathione S-transferases (GSTs) isoenzymes known to be involved in the metabolism of endogenous and exogenous carcinogens in breast cancer tissue to obtain new information on their possible role in tumor progression.
Significance of genetic Polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia Ulusoy, Gulen; Adalı, Orhan; Tumer, Tugba Boyunegmez; Sahin, Gurses; Gozdasoglu, Sevgi; Arinc, Emel (S. Karger AG, 2007-01-01) Background/Aims: The molecular etiology of childhood acute lymphoblastic leukemia (ALL) is likely to involve interactions between environmental factors and genetic make up. Understanding these interactions between various predisposing genes for the risk of developing childhood leukemia is of considerable importance. CYP2E1 is a susceptible gene in this respect, especially for its capacity to bioactivate many procarcinogens including benzene and N-nitrosodimethylamine. The CYP2E1 gene possesses several polym...

Citation Formats

D. C. Kahraman, T. Kahraman, and R. Atalay, “Sequential treatment of HCC cells with PI3K Akt mTOR pathway inhibitors prior to sorafenib attenuates cancer stem cell population,” 2016, vol. 61, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/69607.