GST isoenzymes in matched normal and neoplastic breast tissue

Download
2011-01-01
OĞUZTÜZÜN, SERPİL
Abu-Hijleh, A.
ÇOBAN, TÜLAY
Bulbul, D.
KILIÇ, MURAT
İŞCAN, Mümtaz
İşcan, Mesude
The potential to metabolize endogenous and exogenous substances may influence breast cancer development and tumor growth. Therefore we investigated GST activity and the protein expression of glutathione S-transferases (GSTs) isoenzymes known to be involved in the metabolism of endogenous and exogenous carcinogens in breast cancer tissue to obtain new information on their possible role in tumor progression.

Suggestions

Overexpressed genes/ESTs and characterization of distinct amplicons on 17q23 in breast cancer cells
Erson Bensan, Ayşe Elif; DEMERS, SK; ROUILLARD, JM; HANASH, SM; PETTY, EM (Elsevier BV, 2001-11-01)
17q23 is a frequent site of gene amplification in breast cancer. Several lines of evidence suggest the presence of multiple amplicons on 17q23. To characterize distinct amplicons on 17q23 and localize putative oncogenes, we screened genes and expressed sequence tags (ESTs) in existing physical and radiation hybrid maps for amplification and overexpression in breast cancer cell lines by semiquantitative duplex PCR, semiquantitative duplex RT-PCR, Southern blot, and Northern blot analyses. We identified two d...
Investigaton of chemopreventive properties of Urtica Dioica L., in MCF-7 and MDA231 breast cancer cell lines
Güler, Elif; İşcan, Mesude; Department of Biology (2011)
Cancer is a major health problem in developing world with mostly unsufficient treatment. Cancer prevention through dietary modification appears to be a practical and cost effective possibility. The aim of present study is to investigate the chemical components of “Urtica diocia,L (U. diocia) grown in Turkey” and the possible protective potential of its aqueous extract against breast cancer cell lines. U. diocia was extracted by maceration method which was performed for 6,12, 24, and 36 hours, at 50°C, 37°C,...
Multiscale tumor modeling
Ünsal, Serbülent; Acar, Aybar Can; Department of Health Informatics (2014)
Cancer’s complex behavior decreases success rates of the cancer therapies. The usual steps cancer therapy are, deciding phase of the cancer and planing the therapy according to medical guidelines and there is no room or chance for personalized medicine. Simulation systems that use patient specific data as input and up-to-date scientific evidence as business rules has chance to help clinicians for evidence based personalized medicine practice.In this study our aim is creating a basic model to guide researche...
Synthesis of poly (dl-lactic-co-glycolic acid) coated magnetic nanoparticles for anti-cancer drug delivery
Tansık, Gülistan; Gündüz, Ufuk; Department of Biology (2012)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an extern...
Menadione (Vitamin K3) and Doxorubicin loaded liposomes for enhanced anticancer effect by dual treatment
Akkad, Suzan; Keskin, Dilek; Özen, Can; Department of Biotechnology (2022-9-02)
Chemotherapy is the first line of cancer treatment, but due to its adverse effects, it is set to be limited. Therefore, liposomes are mainly extensively studied to be employed as nanocarriers as they are more advantageous than traditional therapy. They overcome the obstacle of cellular and tissue uptake and improve drugs’ bioavailability, biodistribution and pharmacokinetics. Doxorubicin, an anthracycline drug, is widely used to treat hematological malignancies and solid tumors, to ameliorate its usage a li...
Citation Formats
S. OĞUZTÜZÜN et al., “GST isoenzymes in matched normal and neoplastic breast tissue,” NEOPLASMA, pp. 304–310, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57963.