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Building Dicer1 regulation network of mouse liver hepatocytes
Date
2012-06-29
Author
Ünsal, Şeyma
Beyge, Mahmut
Aydın Son, Yeşim
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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RNA induced gene silencing complex (RISC) has a role in many cellular processes which includes regulation of gene expression, immune response, cell differentiation and embryonic development. Dicer protein is a key regulator of these processes. Dicer1 specifically has central role in maturation of RISC substrate RNA and RISC assembly in mouse. Here the results of a microarray study that investigates the molecular level changes in dicer1 knockout mouse liver hepatocytes is re-analysed and the differentially regulated genes are hierarchically clustered based on molecular function and co-expression to construct the suggested regulation network of Dicer1 in mouse hepatocytes. © 2012 IEEE.
URI
https://hdl.handle.net/11511/69792
DOI
https://doi.org/10.1109/hibit.2012.6209048
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Graduate School of Informatics, Conference / Seminar