Targeted Drug Delivery via Polymer Coated Magnetic Nanoparticles

Gündüz, Ufuk
Targetable magnetic nanoparticles coated with polymers, characterized by high surface-to-volume ratios, are excellent scaffolds for loading targeting moieties, permeation enhancers, imaging tags, and drugs, providing diagnostic and therapeutic capabilities. Magnetic nanoparticles coated with Chitosan, PHB, PEG, Dextran, or PAMAM may be used in cancer drug targeting. Surface modifications of nanoparticles with organic polymers enable stabilization of nanoparticles, reduce agglomeration, provide functional groups, furnish internal cavities for loading of therapeutics and prevent immediate uptake of drug loaded nanoparticles by the reticuloendothelial system.


Targeted Drug Delivery via Chitosan-Coated Magnetic Nanoparticles
Unsoy, Gözde; Gündüz, Ufuk (Elsevier, 2017-01-01)
The devastating effects of chemotherapeutic agents have been observed on healthy cells as well as tumor cells because they are nonspecifically distributed all over the body. This treatment results in hazardous side effects and excessive toxicity. Targeted drug delivery has emerged to overcome the lack of specificity of conventional chemotherapy. Nanoparticles used for drug targeting are promising to circumvent these challenges, by enabling the localization of high drug amounts at the site of disease. When d...
A microarray based expression profiling of paclitaxel and vincristine resistant MCF-7 cells
DEMİREL KARS, MELTEM; Iseri, Ozlem Darcansoy; Gündüz, Ufuk (2011-04-25)
Resistance to the broad spectrum of chemotherapeutic agents in cancer cell lines and tumors has been called multiple drug resistance (MDR). In this study, the molecular mechanisms of resistance to two anticancer agents (paclitaxel and vincristine) in mammary carcinoma cell line MCF-7 were investigated. Drug resistant sublines to paclitaxel (MCF-7/Pac) and vincristine (MCF-7/Vinc) that were developed from sensitive MCF-7 cells (MCF-7/S) were used. cDNA microarray analysis was performed for the RNA samples of...
A labview interface to integrate magnetic resonance imaging (MRI) simulator with system control and its application to regional magnetic resonance electrical impedance tomography (MREIT) reconstruction
Topal, Tankut; Eyüboğlu, Behçet Murat; Department of Electrical and Electronics Engineering (2010)
Magnetic resonance imaging (MRI) is a high resolution medical imaging technique based on distinguishing tissues according to their nuclear magnetic properties. Magnetic resonance electrical impedance tomography (MREIT) is a conductivity imaging technique which reconstructs images of electrical properties, based on their effect on induced magnetic flux density due to externally applied current flow. Both of these techniques are of interest for novel research and development. Simulators help researchers obser...
Targeted delivery of CPG-oligodeoxynucleotide to breast cancer cells by poly-amidoamine dendrimer-modified magnetic nanoparticles
Taghavi Pourianazar, Negar; Gündüz, Ufuk; Gündüz, Güngör; Department of Biotechnology (2016)
One major application of nanotechnology in cancer treatment involves designing nanoparticles to deliver drugs, oligonucleotides, and genes to cancer cells. Nanoparticles should be engineered so that they could target and destroy tumor cells with minimal damage to healthy tissues. This research aims to develop an appropriate and efficient nanocarrier, having the ability of interacting with and delivering CpG-oligodeoxynucleotides (CpG-ODNs) to tumor cells. CpG-ODNs activate Toll-like receptor 9 (TLR9), which...
An Integrated imaging sensor for rare cell detection applications
Altıner, Çağlar; Akın, Tayfun; Eminoğlu, Selim; Department of Micro and Nanotechnology (2012)
Cell detection using image sensors is a novel and promising technique that can be used for diagnostic applications in medicine. For this purpose, cell detection studies with shadowing method are performed with yeast cells (Saccharomyces cerevisiae) using an 32×32 complementary metal oxide semiconductor (CMOS) image sensor that is sensitive to optical illumination. Cells that are placed zero distance from the sensor surface are detected using the image sensor which is illuminated with four fixed leds to main...
Citation Formats
U. Gündüz, “Targeted Drug Delivery via Polymer Coated Magnetic Nanoparticles,” presented at the INTERNATIONAL DNA DAY AND GENOME CONGRESS (IDDGC) 2017, (24 - 28 Nisan 2017), Kırşehir, Türkiye, 2017, Accessed: 00, 2021. [Online]. Available: