A Droplet based Multi-Drug Screening System Controlled with Electrostatic Microvalves

Date

2012-10-28

Author

Yıldırım, Ender
Külah, Haluk

Metadata

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This paper presents a droplet-based drug effect analysis system utilizing electrostatically-actuated normallyclosed microvalves to screen the effect of multiple drugs on a single type of cell. Proposed system minimizes the need for off-chip equipment by utilizing parylene based electrostatic microvalves. Prototypes of the system were fabricated and tested using colored DI water and 3 μm diameter micro beads, emulating drugs and cells respectively. During the tests, micro beads could be successfully entrapped in 137 pl droplets. Tests carried out with yeast cells also yielded successful encapsulation of the cells. It was shown that, switching between the drugs could be achieved by applying 200 V dc to operate the microvalves.

Subject Keywords

Electrostatic, Microvalve, Multi-drug screening, Parylene

URI

https://hdl.handle.net/11511/73239

Conference Name

16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (28 Ekim - 01 Kasım 2012)

Collections

Department of Mechanical Engineering, Conference / Seminar

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Citation Formats

E. Yıldırım and H. Külah, “A Droplet based Multi-Drug Screening System Controlled with Electrostatic Microvalves,” presented at the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (28 Ekim - 01 Kasım 2012), Okinawa; Japan, 2012, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/73239.