High-Throughput Screening and Quantitation of Prohibited Substances in Plasma and UrineSamples by Coated Blade Spray-Mass Spectrometry (CBS-MS)

Tascon, Marcos
Boyacı, Ezel
Gómez-ríos, German A
Pawliszyn, Janusz
Poole, Justen J
Reyes-garcés, Nathaly


High-Throughput Screening and Quantitation of Target Compounds in Biofluids by Coated Blade Spray-Mass Spectrometry
Tascon, Marcos; Gomez-Rios, German Augusto; Reyes-Garces, Nathaly; Poole, Justen; Boyacı, Ezel; Pawliszyn, Janusz (American Chemical Society (ACS), 2017-08-15)
Most contemporary methods of screening and quantitating controlled substances and therapeutic drugs in biofluids typically require laborious, time-consuming, and expensive analytical workflows. In recent years, our group has worked toward developing microextraction (mu e)-mass spectrometry (MS) technologies that merge all of the tedious steps of the classical methods into a simple, efficient, and low-cost methodology. Unquestionably, the automation of these technologies allows for faster sample throughput, ...
High-Pressure-Assisted Extraction of Phenolic Compounds from Olive Leaves: optimization and Comparison with Conventional Extraction
Okur, İlhami; Namlı, Serap; Öztop, Halil Mecit; Alpas, Hami (2023-01-20)
The scope of the study was to optimize high-pressure-assisted extraction (HPAE) conditions for the extraction of phenolic compounds from olive leaves and to compare the optimum HPAE conditions with conventional extraction (CE) (at 50 °C for 30 min). In this regard, different treatment pressure levels (300-500 MPa), time (5-15 min), and solid-to-solvent ratios (0.1-0.3 w/v) were used to optimize the total phenolic content (TPC) and oleuropein content by using the Box-Behnken design. According to the results,...
High-quality alignment of nematic liquid crystals using periodic nanostructures created by nonlinear laser lithography
Pavlov, Ihor; Dobrovolskiy, A. M.; Kadan, V. M.; Blonskiy, I. V.; Kazantseva, Z. I.; Gvozdovskyy, I. A. (2018-10-01)
It is well known that today two main and well studied methods for alignment of liquid crystals has been used, namely: rubbing and photoalignment technologies, that lead to the change of anisotropic properties of aligning layers and long-range interaction of the liquid crystal molecules in a mesophase. In this manuscript, we use the nonlinear laser lithography technique, which was recently presented as a fast, relatively low-cost method for a large area micro and nanogrooves fabrication based on laser-induce...
High-Performance Harmonic Isolation and Load Voltage Regulation of the Three-Phase Series Active Filter Utilizing the Waveform Reconstruction Method
Senturk, Osman S.; Hava, Ahmet Masum (Institute of Electrical and Electronics Engineers (IEEE), 2009-11-01)
This paper develops a waveform reconstruction method (WRM) for high accuracy and bandwidth signal decomposition of voltage-harmonic-type three-phase diode rectifier load voltage into its harmonic and fundamental components, which are utilized in the series active filter (SAF) control algorithms. The SAF-compensated system utilizing WRM provides high-performance load harmonic voltage isolation and load voltage regulation at steady-state and during transients compared to the system utilizing the synchronous r...
high-level expression of hepatitis b surface antigen in pichia pastoris, its purification and immunological characterization
Selamoğlu, Hande; Özcengiz, Gülay; Department of Biotechnology (2009)
Hepatitis B virus (HBV), which belongs to the family Hepadnaviridae, is responsible for acute and chronic hepatitis. The vaccines presently used to immunize patients against HBV are recombinant subunit vaccines consisting of viral surface antigens (S protein). However, they are expensive and their use is limited in poor countries. For that reason, HBV remains an important worldwide health problem. Of the 2 billion people who have been infected with the HBV, more than 350 million have chronic (lifelong) infe...
Citation Formats
M. Tascon, E. Boyacı, G. A. Gómez-ríos, J. Pawliszyn, J. J. Poole, and N. Reyes-garcés, “High-Throughput Screening and Quantitation of Prohibited Substances in Plasma and UrineSamples by Coated Blade Spray-Mass Spectrometry (CBS-MS),” 2017, Accessed: 00, 2021. [Online]. Available: https://pittcon.org/2017/Pittcon-2017-Technical-Program.pdf.