Molecular Biology of Liver Cancer

Tulin, Ersahin
Öztürk, Mehmet
Atalay, Rengül
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related mortality worldwide. Recent advances in the molecular profiling of HCC emphasize its intratumoral heterogeneity and reveal how cellular pathways are altered in favor of tumor progression. Malignant transformation of primary liver cancer is achieved through the acquisition of cancer hallmark capabilities that promote the uncontrolled proliferation of hepatocytes. In this review, the characteristics and acquired capabilities of human primary liver cancer, based on the HCC‐specific genetic and epigenetic alterations, are described and discussed


In vitro autocrine secretion of inflammatory cytokines in response to drug stress in HCC and LCSC populations
Kalem Yapar, Nisan Ece; Muyan , Mesut; Kahraman, Deniz Cansen; Department of Biology (2022-1-26)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality. Regardless of its etiology, HCC originates from the constant wound-healing response subsequent to cell death and resulting in a cascade of inflammation. Hence, understanding the importance of inflammatory markers in HCC lies a great importance. A well-known pro-inflammatory cytokine; interleukin-6 has been numerously reported in the sera of HCC patients. This study investigated the effects of IL-6 stimulation in HCC cel...
Statistical estimation applied to electrocardiographic imaging
Serinağaoğlu Doğrusöz, Yeşim (2019-05-01)
Cardiovascular diseases are among the leading causes of death all over the world. Researchers have been extensively working on methods for early diagnosis and treatment of these diseases, with the goal of decreasing these death tolls. In Electrocardiographic Imaging (ECGI), the electrical activity of the heart is estimated from electrocardiographic measurements obtained from the body surface, using densely distributed electrodes, and a mathematical model of the body. This technique has advantages over class...
Selenium alters the lipid content and protein profile of rat heart: An FTIR micro spectroscopic study
Toyran, Neslihan; Turan, Belma; Severcan, Feride (Elsevier BV, 2007-02-15)
Cardiovascular disease is one of the most important causes of morbidity and mortality in Western countries. In addition, it is well documented that selenium (Se) deficiency has been linked to cardiovascular diseases. This study was undertaken to present the effect of sodium selenite on left and right myocardia, and small veins of normal control rat heart at molecular level by using Fourier transform infrared (FTIR) microspectroscopy. The results mainly reveal that, Se treatment causes an increase in lipid c...
Cancer modeling via biologically validated genes
Karakelle, Barış Su; Purutçuoğlu Gazi, Vilda; Ürün, Yüksel (2017-05-10)
The cancer disease is the second most common disease type seen after the frequency of the cardiovascular diseases. The frequency of this genetic disease changes with respect to the gender. Accordingly, the gynecological cancer, which covers ovarian, endometrial or cervical cancer, is the second most common cancer type in women after the breast cancer. Similar to other cancer types, the gynecological cancer is the system disease, meaning that the malfunctions and mutations in the gene regulatory ...
Molecular investigation of therapeutical effects of Ɣ-tocotrienol conjugation therapy with doxorubicin on hepatocellular carcinoma cell line HePG2
Özyurt, İpek; Son, Çağdaş Devrim; Department of Biology (2017)
Hepatocellular carcinoma (HCC) is the fifth leading tumor of the liver tissue in terms of frequency of occurrence and third in terms of mortality. Even though, the most widely used chemotherapeutic agent doxorubicin in treatment of HCC had a great impact for development of therapeutic strategies preventing the progression of tumor formation and elucidating the physiological characteristics of tumor tissue. Moreover, use of doxorubicin minimizes the side effects of the drug in the individual and prevents the...
Citation Formats
E. Tulin, M. Öztürk, and R. Atalay, Molecular Biology of Liver Cancer. 2015, p. 243.