Molecular Biology of Liver Cancer

Date

2015-01-01

Author

Tulin, Ersahin
Öztürk, Mehmet
Atalay, Rengül

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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related mortality worldwide. Recent advances in the molecular profiling of HCC emphasize its intratumoral heterogeneity and reveal how cellular pathways are altered in favor of tumor progression. Malignant transformation of primary liver cancer is achieved through the acquisition of cancer hallmark capabilities that promote the uncontrolled proliferation of hepatocytes. In this review, the characteristics and acquired capabilities of human primary liver cancer, based on the HCC‐specific genetic and epigenetic alterations, are described and discussed

URI

http://onlinelibrary.wiley.com/book/10.1002/3527600906
https://hdl.handle.net/11511/75702

Relation

Reviews in Cell Biology and Molecular Medicine

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Graduate School of Informatics, Book / Book chapter

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Citation Formats

E. Tulin, M. Öztürk, and R. Atalay, Molecular Biology of Liver Cancer. 2015, p. 243.