Selenium alters the lipid content and protein profile of rat heart: An FTIR micro spectroscopic study

Date

2007-02-15

Author

Toyran, Neslihan
Turan, Belma
Severcan, Feride

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

192
views

0
downloads

Cardiovascular disease is one of the most important causes of morbidity and mortality in Western countries. In addition, it is well documented that selenium (Se) deficiency has been linked to cardiovascular diseases. This study was undertaken to present the effect of sodium selenite on left and right myocardia, and small veins of normal control rat heart at molecular level by using Fourier transform infrared (FTIR) microspectroscopy. The results mainly reveal that, Se treatment causes an increase in lipid content both in the saturated and unsaturated lipids, and an alteration in protein profile with a decrease in a-helix and an increase in beta-sheet structure of the rat heart which might be reflecting a slight subtoxic effect of selenium supplementation on normal rat heart at the dose used in this study. (c) 2006 Elsevier Inc. All rights reserved.

Subject Keywords

Biophysics, Biochemistry, Molecular Biology

URI

https://hdl.handle.net/11511/57066

Journal

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

DOI

https://doi.org/10.1016/j.abb.2006.12.012

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Statistical estimation applied to electrocardiographic imaging Serinağaoğlu Doğrusöz, Yeşim (2019-05-01) Cardiovascular diseases are among the leading causes of death all over the world. Researchers have been extensively working on methods for early diagnosis and treatment of these diseases, with the goal of decreasing these death tolls. In Electrocardiographic Imaging (ECGI), the electrical activity of the heart is estimated from electrocardiographic measurements obtained from the body surface, using densely distributed electrodes, and a mathematical model of the body. This technique has advantages over class...
Rapid monitoring of diabetes-induced lipid peroxidation by Fourier transform infrared spectroscopy: Evidence from rat liver microsomal membranes Severcan, F; Gorgulu, G; Gorgulu, ST; Güray, Nülüfer Tülün (Elsevier BV, 2005-04-01) Increased oxidative stress is the consequence of either enhanced reactive oxygen species (ROS) production or attenuated ROS scavenging capacity, resulting in tissue damage that in most instances is assessed by the measurement of lipid peroxides. In the current study, diabetes-induced lipid peroxidation in rat liver microsomal membranes was investigated by Fourier transform infrared (FT-IR) spectroscopy at different temperatures. The olefinic (=CH) band at 3012 cm(-1) was used to probe diabetes-induced lipid...
Cancer modeling via biologically validated genes Karakelle, Barış Su; Purutçuoğlu Gazi, Vilda; Ürün, Yüksel (2017-05-10) The cancer disease is the second most common disease type seen after the frequency of the cardiovascular diseases. The frequency of this genetic disease changes with respect to the gender. Accordingly, the gynecological cancer, which covers ovarian, endometrial or cervical cancer, is the second most common cancer type in women after the breast cancer. Similar to other cancer types, the gynecological cancer is the system disease, meaning that the malfunctions and mutations in the gene regulatory ...
Molecular Biology of Liver Cancer Tulin, Ersahin; Öztürk, Mehmet; Atalay, Rengül (2015-01-01) Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‐related mortality worldwide. Recent advances in the molecular profiling of HCC emphasize its intratumoral heterogeneity and reveal how cellular pathways are altered in favor of tumor progression. Malignant transformation of primary liver cancer is achieved through the acquisition of cancer hallmark capabilities that promote the uncontrolled proliferation of hepatocytes. In this review, the characteristics and acquired capabilities of huma...
Virtual Heart Models: Multi-Physics Approaches to Computational Cardiology (VHEART) Göktepe, Serdar(2015-8-31) Heart disease is the number one cause of death in industrialized nations. Despite the broad class of treatment techniques such as medication, surgery and tissue-engineered therapies, heart disease remains to be one of the most frequent, disabling, and life-threatening diseases. In Europe it accounts for almost half of overall annual mortality rate. In the European Union (EU) alone, cardiovascular disease causes over 2 million deaths per year. The cost of cardiovascular disease to the EU economy is €192 bill...

Citation Formats

N. Toyran, B. Turan, and F. Severcan, “Selenium alters the lipid content and protein profile of rat heart: An FTIR micro spectroscopic study,” ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, pp. 184–193, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/57066.