Programmed proteolytic machineries of Thermoplasma volcanium



Sequential growth factor delivery from complexed microspheres for bone tissue engineering
Basmanav, F. Buket; KÖSE, GAMZE; Hasırcı, Vasıf Nejat (2008-11-01)
Aim of the study was to design a 3D tissue-engineering scaffold capable of sequentially delivering two bone morphogenetic proteins (BMP). The novel delivery system consisted of microspheres of polyelectrolyte complexes of poly(4-vinyl pyridine) (P4VN) and alginic acid loaded with the growth factors BMP-2 and BMP-7 which themselves were loaded into the scaffolds constructed of PLGA. Microspheres carrying the growth factors were prepared using polyelectrolyte solutions with different concentrations (4-10%) to...
Sequential growth factor delivery from complexed microspheres for bone tissue engineering
Başmanav, Fitnat Buket; Hasırcı, Vasıf Nejat; Department of Biotechnology (2007)
Complexed microspheres of poly(4-vinyl pyridine) (P4VN) and alginic acid were prepared by internal gelation method and subsequent freeze drying. The 4% and 10% microspheres were loaded with Bone Morphogenetic Protein-2 (BMP-2) and Bone Morphogenetic Protein-7 (BMP-7), respectively for in vitro studies and were entrapped in PLGA foams. Foams containing only 4%, BMP-2 microspheres, only 10%, BMP-7 microspheres and both populations were prepared. Control samples of each group were prepared with drug free micro...
Sequential growth factor delivery from polymeric scaffolds for bone tissue engineering
Yılgör, Pınar; Hasırcı, Nesrin; Department of Biotechnology (2009)
Tissue engineering is a promising alternative strategy to produce artificial bone substitutes; however, the control of the cell organization and cell behavior to create fully functional 3-D constructs has not yet been achieved. To overcome these, activities have been concentrated on the development of multi-functional tissue engineering scaffolds capable of delivering the required bioactive agents to initiate and control cellular activities. The aim of this study was to prepare tissue engineered constructs ...
Simulated annealing for the generation of pareto fronts with aerospace applications /
Karslı, Gizem; Tekinalp, Ozan; Department of Aerospace Engineering (2004)
Mercadier, Deniz Sayin; Beşbınar, Beril; Frossard, Pascal (2019-01-01)
Accurate and fast segmentation of nuclei in histopathological images plays a crucial role in cancer research for detection and grading, as well as personal treatment. Despite the important efforts, current algorithms are still suboptimal in terms of speed, adaptivity and generalizability. Popular Deep Convolutional Neural Networks (DCNNs) have recently been utilized for nuclei segmentation, outperforming traditional approaches that exploit color and texture features in combination with shallow classifiers o...
Citation Formats
S. Kocabıyık, “Programmed proteolytic machineries of Thermoplasma volcanium,” 2005, Accessed: 00, 2021. [Online]. Available: 0.