Doxorubicin Loaded Dextran Coated Magnetic Nanoparticles Changes Gene Expression Levels in Breast Cancer Cell Lines

Date

2015-11-27

Author

Yalçın Azarkan, Serap
Ünsoy, Gözde
Khodadust, R
Mutlu, Pelin
Gündüz, Ufuk

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https://hdl.handle.net/11511/78394

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Doxorubicin-Loaded Dextran Coated Magnetic Nanoparticles Affect on Cytokines Gene Expression in Breast Cancer Cell Line Yalçın Azarkan, Serap; Mutlu, Pelin; Gündüz, Ufuk (null; 2017-04-24) Aims and Scopes: IL-6 and IL-8 are a well-known proinflammatory cytokines. IL-8 contributes to cancer progression through its potential functions as a mitogenic, motogenic and angiogenic factor. Interleukin (IL)-6 has important roles in the proliferation and metastasis[1,2]. In the present study, Dextran coated magnetic nanoparticles (Dox-Dex-MNPs) were prepared to obtain an effective targeted delivery system for Doxorubicin on breast cancer cell line. Materials and Methods: Dox-Dex-MNPs were synthesized an...
Doxorubicin-loaded magnetic nanoparticles downregulate expression of anti-apoptotic genes in resistant breast cancer cells. Yalçın Azarkan, Serap; Mutlu, Pelin; Ünsoy, Gözde; Khodadust, Rouhollah; Gündüz, Ufuk (2020-06-01)
Doxorubicin loading, release, and stability of polyamidoamine dendrimer-coated magnetic nanoparticles Rouhollah, Khodadust; Pelin, Mutlu; Serap, Yalcin; Gozde, Unsoy; Ufuk, Gunduz (Elsevier BV, 2013-06-01) Nanotechnology is a promising alternative to overcome the limitations of classical chemotherapy. As a novel approach, dendrimer-coated magnetic nanoparticles (DcMNPs) maintain suitable drug delivery system because of their buildup of functional groups, symmetry perfection, nanosize, and internal cavities. They can also be targeted to the tumor site in a magnetic field. The aim of this study is to obtain an effective targeted delivery system for doxorubicin, using polyamidoamine (PAMAM) DcMNPs. Different gen...
Doxorubicin Loaded Dextran Coated Magnetic Nanoparticles Enhance Cytotocity in Doxorubicin Yalçın Azarkan, Serap; Gözde, Ünsoy; Khodadust, R; Gündüz, Ufuk (2015-06-09)
Doxorubicin exhibits strong and selective association with VEGF Pu22 G-quadruplex Bilgen, Ecenaz; Persil Çetinkol, Özgül (Elsevier BV, 2020-12-01) Background: Vascular endothelial growth factor (VEGF), is upregulated in tumor cells and thus became a potential therapeutic target for anti-cancer drugs. Recent reports suggested the use of Doxorubicin (Dox) with VEGF-targeting siRNAs for an enhanced decrease in VEGF expression. Besides, VEGF-B gene therapy was found to suppress the cardiotoxicity effects of Dox. On the other hand, even though Dox is a commonly used anti-cancer agent, its mechanism of actions isn't completely mapped out. Herein, the intera...

Citation Formats

S. Yalçın Azarkan, G. Ünsoy, R. Khodadust, P. Mutlu, and U. Gündüz, “Doxorubicin Loaded Dextran Coated Magnetic Nanoparticles Changes Gene Expression Levels in Breast Cancer Cell Lines,” 2015, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/78394.