The Effect of Sin3a Complex on Cell Cycle and Cell Death in Mouse Embryonic Stem Cells



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The Effect of 15-lipoxygenase-1 (15-LOX-1) on angiogenesis in colorectal and prostate cancer
Çolakoğlu, Melis; Banerjee, Sreeparna; Department of Biology (2017)
15-lipoxygenase-1 (15-LOX-1) is one of the lipoxygenases (LOX) that are important for the generation of inflammatory bioactive lipids, which then result in the initiation and resolution of inflammation. The enzyme mainly metabolizes the omega-6 fatty acid, linoleic acid, to 13-(S)-HODE. In colorectal carcinoma, the tumor suppressive role of 15-LOX-1 is highlighted with decreased proliferation, induction of apoptosis, reduced motility and invasion. Oppositely, the expression of 15-LOX-1 was reported to have ...
Culfa, Şeyda; Son, Çağdaş Devrim; Bek, Alpan; Department of Biochemistry (2022-8-29)
Cells' interaction with their environment and how their responses to different mechanical cues are regulated have attracted attention for decades. These mechanical cues vary from topography to substrate stiffness. Knowing how topography-induced cell responses are regulated might give useful information about cell behaviors in health and disease states. This knowledge can be utilized to manipulate cell behaviors for different purposes. Topography-dependent cell behaviors rely on various parameters such as ce...
The role of multiple toll-like receptor signalling cascades on interactions between biomedical polymers and dendritic cells
Shokouhi, Behnaz; Coban, Cevayir; Hasırcı, Vasıf Nejat; Aydin, Erkin; Dhanasingh, Anandhan; Shi, Nian; Koyama, Shohei; Akira, Shizuo; Zenke, Martin; Sechi, Antonio S. (2010-08-01)
Biomaterials are used in several health-related applications ranging from tissue regeneration to antigen-delivery systems. Yet, biomaterials often cause inflammatory reactions suggesting that they profoundly alter the homeostasis of host immune cells such as dendritic cells (DCs). Thus, there is a major need to understand how biomaterials affect the function of these cells. In this study, we have analysed the influence of chemically and physically diverse biomaterials on DCs using several murine knockouts. ...
Citation Formats
G. Güven and N. Terzi Çizmecioğlu, “The Effect of Sin3a Complex on Cell Cycle and Cell Death in Mouse Embryonic Stem Cells,” 2019, Accessed: 00, 2021. [Online]. Available: