The Effect of Sin3a Complex on Cell Cycle and Cell Death in Mouse Embryonic Stem Cells



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The Effect of 15-lipoxygenase-1 (15-LOX-1) on angiogenesis in colorectal and prostate cancer
Çolakoğlu, Melis; Banerjee, Sreeparna; Department of Biology (2017)
15-lipoxygenase-1 (15-LOX-1) is one of the lipoxygenases (LOX) that are important for the generation of inflammatory bioactive lipids, which then result in the initiation and resolution of inflammation. The enzyme mainly metabolizes the omega-6 fatty acid, linoleic acid, to 13-(S)-HODE. In colorectal carcinoma, the tumor suppressive role of 15-LOX-1 is highlighted with decreased proliferation, induction of apoptosis, reduced motility and invasion. Oppositely, the expression of 15-LOX-1 was reported to have ...
Culfa, Şeyda; Son, Çağdaş Devrim; Bek, Alpan; Department of Biochemistry (2022-8-29)
Cells' interaction with their environment and how their responses to different mechanical cues are regulated have attracted attention for decades. These mechanical cues vary from topography to substrate stiffness. Knowing how topography-induced cell responses are regulated might give useful information about cell behaviors in health and disease states. This knowledge can be utilized to manipulate cell behaviors for different purposes. Topography-dependent cell behaviors rely on various parameters such as ce...
The Effect of SETD3 on Beta-Catenin and Canonical Wnt Signaling Pathway Activity in Mouse Embryonic Stem Cells
Alganatay, Ceren; Terzi Çizmecioğlu, Nihal; Department of Molecular Biology and Genetics (2023-1-16)
Mouse embryonic stem cells (mESCs) are self-renewing, pluripotent cells that can differentiate into endoderm, mesoderm and neuroectoderm. As differentiation requires deactivation of pluripotency factors and activation of germ layer specific genes, many epigenetic factors play an essential role. A previously performed shRNA screen showed that SETD3 which is a SET-domain containing epigenetic factor, is an essential factor for mesendoderm differentiation of mESCs. Our preliminary data demonstrated that when m...
Citation Formats
G. Güven and N. Terzi Çizmecioğlu, “The Effect of Sin3a Complex on Cell Cycle and Cell Death in Mouse Embryonic Stem Cells,” 2019, Accessed: 00, 2021. [Online]. Available: