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kiral Tetrahidropridin bileşiklerinin enzimatik rezolüsyon yolu üzerinden sentezi
Date
2017-09-14
Author
Tanyeli, Cihangir
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https://hdl.handle.net/11511/87265
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Synthesis of chiral aziridinyl phosphonates, their biological activities and organocatalytic effect of their phosphonic acid derivatives
Beksultanova, Nurzhan; Doğan, Özdemir; Department of Chemistry (2017)
Aziridines are important three-membered heterocyclic ring systems in synthetic organic chemistry and medicinal chemistry. They can be used as the building blocks for the synthesis of amino acids, amino alcohols, pyrrolidines, pyrroles, lactams, and oxazoles. Aziridinyl phosphonates are attracting more attention in recent years. They are the precursors of α-amino phosphonates that find applications such as enzyme inhibitors and antibacterial agents. One of the methods for the synthesis of these compounds is ...
Synthesis of heteroaryl substituted dihydrofuran and dihydropyran derivatives by green chemistry approach
Demirci, Sema; Tanyeli, Cihangir; Department of Chemistry (2009)
The thesis subject is mainly involved in Green Chemistry approach. Thiophene, furan and pyridine carboxaldehydes were chosen as starting compounds and vinylation and allylation with Grignard reaction afforded the corresponding racemic heteroaryl substituted allylic and homoallylic alcohols. Subsequent resolution with enzymes (PS-Amano II, Lipozym and Novazym 435) gave enantiomerically enriched alcohols with the e.e. values varied between 65 and 99%. The absolute configurations of all substrates are known. A...
Synthesis and characterization of hydrogels from allyl methacrylate and acrylamide copolymer
Ayazoğlu, Neslihan; Usanmaz, Ali; Keskin, Selda; Department of Polymer Science and Technology (2011)
Acrylamide based hydrogels were synthesized through copolymerization reaction of allyl methacrylate with acrylamide. Copolymerization reactions were carried out with solution polymerization in tetrahydrofuran by using α-α-azoisobutyronitrile as an initiator at 60 0 C. Three copolymer compositions were studied having 5, 15, 25 molar percentage of allyl methacrylate as feed concentrations. The synthesized copolymers were characterized by FTIR, NMR, DSC, TGA and GPC. 1H-NMR spectra were used to confirm the che...
Asymmetric synthesis of chiral camphor fused pyridine type novel organocatalysts
Küçükdişli, Murat; Tanyeli, Cihangir; Department of Chemistry (2009)
Chiral pyridines as organocatalysts have been used in asymmetric organic synthesis in recent years. The asymmetric synthesis of camphor fused pyridine type novel organocatalysts were perfomed starting from cheap and easily available natural (+)-camphor. Using camphor fused pyridine skeleton, six organocatalysts 29, 32, 33, 38, 40, and 41were successfully synthesized. The first four nucleophilic and Lewis base catalysts 29, 32, and 33 are different P-oxides and P,N-dioxides which were tested in allylation of...
Chiral 2-aminodmap/sulfonamides and squaramides as bifunctional acid/base organocatalysts in asymmetric catalysis
Işık, Murat; Tanyeli, Cihangir; Department of Chemistry (2011)
Synthesis and evaluation of catalytic performances of novel bifunctional 2- aminoDMAP-Thiourea/ Sulfonamide/ Squaramide organocatalysts derived from trans-(R,R)-cyclohexane-1,2-diamine forms the main goal of this thesis. For this purpose, direct selective mono-N-pyridilization of trans-(R,R)-cyclohexane-1,2- diamine via Pd and Cu catalysis is described successfully first. Facile preparation of chiral 2-aminoDMAP core catalaphore led to the development of various 2- aminoDMAP- Thiourea/ Sulfonamides/ Squaram...
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C. Tanyeli, “kiral Tetrahidropridin bileşiklerinin enzimatik rezolüsyon yolu üzerinden sentezi,” 2017, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/87265.