The Role of Nek 6 Gene Expression in Multidrug Resistance and Apoptosis in MCF 7 and K 562 Cell Lines

Ayça, Nabioğlu
Pelin, Mutlu
Yalçın Azarkan, Serap
Gündüz, Ufuk
EACR - The Europian cancer Organization ; Anticancer Drug Action and Drug Resistance: from Cancer Biology to the Clinic, 20 - 23 Haziran 2015,


The Role of NEK6 gene expression in multidrug resistance and apoptosis in MCF-7 and K-562 cell lines
Nabioğlu, Ayça; Gündüz, Ufuk; Mutlu, Pelin; Department of Biology (2015)
Grey mold disease is one of these postharvest decays. Especially grapes are infected by Botrytis cinerea known as a causal agent of the grey mold disease. Some fungicides are used to control this disease. However, they cause funcide- resistant strains of the pathogens and make hazardous for human health and environmental safety. Therefore, The killer yeasts are considered as promising alternative antifungal agents among other biocontrol agents. Pichia anomala which is a killer yeast secretes the K5 type yea...
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Alpsoy, Aktan; Gündüz, Ufuk; Department of Biology (2014)
Even though chemotherapy keeps its position as the most preferred and potent strategy of cancer treatment, resistance of tumor to the anti-neoplastic drug poses an obstacle for chemotherapy success. Multidrug resistance (MDR) is a phenomenon that is defined as the intrinsic or acquired resistance against structurally and functionally unrelated drugs. Acquisition of multidrug resistance can be through several distinct mechanisms such as increased drug efflux by ABC transporters, increased drug detoxification...
The Role of AKR1B10 in Oxidative Stress Response in Hepatocellular Carcinoma
Tuğral, Hoşnaz; Banerjee, Sreeparna; Department of Biology (2022-2-8)
Hepatocellular carcinoma (HCC) is projected to account for 4.7 percent of all new cancer cases and 8.2 percent of all cancer-related deaths globally. NADPH- dependent aldoketoreductases (AKRs) can reduce carbonyl substrates like glucose, sugar aldehydes, keto-steroids, keto-prostaglandins, retinals, quinones, and lipid peroxidation by-products. A member of this family of enzymes, AKR1B10, is thought to be a robust early marker for HCC as well as a predictor of poor prognosis. Oxidative stress in cells may r...
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Citation Formats
N. Ayça, M. Pelin, S. Yalçın Azarkan, and U. Gündüz, “The Role of Nek 6 Gene Expression in Multidrug Resistance and Apoptosis in MCF 7 and K 562 Cell Lines,” Florence Italy, 2015, p. 103, Accessed: 00, 2021. [Online]. Available: