Department of Biology, Thesis

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Thesis (584)

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Author
Afkhami, Pervaneh (2)
Aktaş, Caner (2)
Ambarlı, Hüseyin (2)
Atalay, Zeynep (2)
Ateş, Mevlüde Alev (2)

Subject
Biology. (49)
Genetics. (31)
Natural Sciences (22)
Breast (16)
Gene expression. (15)

Date Issued
1988 - 1989 (2)
1990 - 1999 (115)
2000 - 2009 (166)
2010 - 2019 (265)
2020 - 2022 (35)

Item Type
Master Thesis (426)
Ph.D. Thesis (158)

Recent Submissions

Investigation of effects of hyperlipidemia on IRE1α and insulin pathway in the cerebral cortex of ApoE-/- mice AK, Deniz; Yanık, Tülin; Department of Molecular Biology and Genetics (2022-1-20) Obesity prevalence increases worldwide. The most crucial reason for obesity is high-fat diet (HFD). Serum fatty acid levels are increased with HFD, inducing inflammation and glucose homeostasis disruption, leading to insul...
EFFECTS OF DISSOLVED ORGANIC CARBON (DOC) AND ZOOPLANKTON GRAZING PRESSURE ON BACTERIA AND CILIATES Yetim, Sinem; Beklioğlu, Meryem; Ger, Kemal Ali; Department of Biology (2021-11-24) Global climate change results in extreme precipitation events that increase allochthonous organic matter (e.g., dissolved organic carbon, DOC) input into freshwater ecosystems via flooding. While DOC is a source of carbon ...
Sorting nexin 3 (SNX3) is an immediate and sustained target of EGF stimulation in EGFR positive breast cells Çiçek, Esra; Erson Bensan, Ayşe Elif; Department of Biology (2021-9-10) Sorting nexin 3 (SNX3) is a member of the sorting nexins family, which is involved in the endocytic trafficking network. SNX3 only has a PX domain, which helps endosomes bind to phosphatidyl inositol-3-phosphate and plays ...
Generation and Characterization of Induced Pluripotent Stem Cell Lines From Multiple Sclerosis Patients and Healthy Individuals Begentaş, Onur Can; Kiriş, Erkan; Department of Molecular Biology and Genetics (2021-9-8) Multiple Sclerosis (MS) is an autoimmune disease characterized by inflammation, demyelination, and axonal damage resulting in neurodegeneration in the central nervous system (CNS). Relapsing-remitting MS (RRMS) is the most...
Bioactivity analysis of novel indole derivatives on hepatocellular carcinoma as sirtuin inhibitors Bınarcı, Büşra; Muyan, Mesut; Kahraman, Deniz Cansen; Department of Molecular Biology and Genetics (2021-9-8) Hepatocellular carcinoma is ruthless cancer, a subtype of primary liver cancer and affects many people with various ethnic backgrounds and age intervals. Indole derivative molecules are potent chemicals used in several dru...
A brighter method to illuminate the dark side of adhesion G protein-coupled receptors: detection of the ADGRG1 dimers by Bioluminescence Resonance Energy Transfer (BRET) Murat, Merve; Son, Çağdaş Devrim; Cevheroğlu, Orkun; Department of Molecular Biology and Genetics (2021-9-7) G protein-coupled receptors (GPCRs) form oligomeric complexes in living cells, and these complex structures affect the receptor maturation, trafficking, and signaling processes. Adhesion G protein-coupled receptors (aGPCRs...
COMPARISON OF METHYLATION PATTERNS IN ANCIENT HUNTER-GATHERERS AND FARMERS Çokoğlu, Sevim Seda; Somel, Mehmet; Department of Biology (2021-9) As the Neolithic transition dramatically changed human lifestyle and diet, one may expect epigenetic differences between pre-Neolithic Hunter-Gatherers (HGs) and Neolithic farmers (NFs) (Childe, 1940). In this study, we in...
INVESTIGATION OF EFFECTS OF VITAMIN D AND VITAMIN D METABOLIZING CYP450 ISOZYMES ON MULTIPLE SCLEROSIS PATHOPHYSIOLOGY IN ANIMAL MODEL BY MOLECULAR APPROACHES Evin, Emre; Adalı, Orhan; Department of Biology (2021-8) Multiple sclerosis (MS) is a complicated, recurrent, and often progressive inflammatory demyelinating autoimmune disease of the central nervous system, yet etiopathogenesis remains unsolved. MS frequency increases with inc...
A PROBABILISTIC ASSESSMENT OF SARS-COV-2 HOST INTERACTIONS IN THE CONTEXT OF META-COMMUNITY AND URBAN ECOLOGY Nehri, Leman Nur; Eroğlu, Seçkin; Department of Biology (2021-6-29) Coronavirus disease 2019 (COVID-19) is an ongoing pandemic that was detected in Wuhan, China, in December 2019 and spread all around the world. COVID-19 is caused by Severe acute respiratory syndrome coronavirus 2 (SARS-Co...
ANALYSIS OF TRANSCRIPTOME DATA FOR THE EVALUATION OF METABOLIC DEREGULATION IN CANCER Sheraj, Ilir; Banerjee, Sreeparna; Department of Biology (2021-6-28) The great potential of cancer metabolism in tumor development as well as treatment has been appreciated in recent years. In this study, an extensive list of enzymes relevant to central cellular metabolism and metabolite tr...
Selecting 2-FY RNA Aptamers Against SARS-CoV-2 Particle Öztürk, Meriç; Gözen, Ayşe Gül; İlgü, Müslüm; Department of Molecular Biology and Genetics (2021-6-22) Corona Virus Disease – 19 (COVID-19) is caused by infection of SARS-CoV-2 from other humans and animals, which results in clinical symptoms like fever, cough, breathing difficulties headache, muscle pain, and diarrhea. Fur...
Comparative transcriptomics of bacillus subtilisbacilysin-negative genotype with particular reference to bacilysin formation Kocabay, Naz; Özcengiz, Gülay; Department of Molecular Biology and Genetics (2021-2-15) The Gram-positive model prokaryote Bacillus subtilisis a non-pathogenic organism that is known for producing a wide variety of secondary metabolites with pharmacological andantimicrobial activities.The smalle...
Small molecule ubiquitin-proteasome system inhibitor library screen reveals botulinum neurotoxin type a inhibitors Şen, Edanur; Kiriş, Erkan; Department of Biology (2021-2-15) Botulinum neurotoxins (BoNTs), known as the most potent bacterial toxins, cause potentially lethal disease botulism. BoNTs are classified as category A bioterror agents by many countries because they are easy to produce an...
Genetic diversity differences between parental and progeny population of populus euphratica populations in a fragmented river ecosystem Çelik, Mert; Kaya, Zeki; Department of Biology (2021-2-15) Euphrates poplar, also known as desert poplar in the literature, grows along riverbanks in arid and semi-arid regions and is well-known for its high tolerance to broad temperature changes, drought, and soils with high salt...
Evaluation of functional changes in akr1b1 and akr1b10 overexpressing colorectal cancer cell lines Güderer, İsmail; Banerjee, Sreeparna; Department of Biology (2021-2-15) Aldo-keto reductases (AKRs) are nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzymes with diverse cellular metabolism functions. AKR1B1 and AKR1B10 are two of the most studied enzymes in the AKR family. AK...
The effect of plant diversity and ground cover onseedling establishment of diplotaxis tenuifolia(l.) dc. in the central anatolian steppe Kaplan, Ekin; Bilgin, Cemal Can; Tavşanoğlu, Çağatay; Department of Biology (2021-2-15) Invasive exotic plants increasingly pose a threat to native biodiversity in many parts ofthe world. However, they have rarely become successful in Turkey. One hypothesissuggests a highly diverse native flora avoids estab...
Optimization of a translating ribosomal affinity purification method Gürcüoğlu, Irmak; Erson Bensan, Ayşe Elif; Department of Biology (2021-2-10) Novel technologies revealed an immense transcriptome complexity in normal and in cancer cells. One of the reasons for this complexity is isoform variability in cancer cells. Transcript isoforms can arise due to alternative...
Convergent evolution of primate testis transcriptomes in response to mating strategy differences Yapar, Etka; Somel, Mehmet; Department of Biology (2021-2-01) In independent mammalian lineages where females mate with multiple males (multimale mating strategies), males have evolved larger testicles relative to those lineages where females mate with fewer males (single-male mating...
Identification of protein partners of setd3 in mouse embryonic stem cells Güven, Gözde; Terzi Çizmecioğlu, Nihal; Department of Molecular Biology and Genetics (2021-1-26) Embryonic development is a highly coordinated process that contains rapid cell divisions. During this time, the cells also start differentiation, and at the end of development, the cells become fully differentiated. This d...
The regulation of the CXXC5 gene expression Yaşar, Pelin; Muyan, Mesut; Department of Molecular Biology and Genetics (2021-1-19) 17β-estradiol (E2) is the main circulating estrogen hormone in the body and is involved in the physiological and pathophysiological regulation of various tissue notably mammary tissue functions. E2 is responsible for cellu...

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