Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme

Date

2021-03-01

Author

Yalcin, Serap
Gündüz, Ufuk

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Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and MCF-7/1000 Etoposide resistance cells. For this purpose, PHB covered iron oxide-based magnetic nanoparticles (PHB-MNPs) were prepared by coprecipitation. We used magnetic nanoparticles because they include highly targeted to tumors in vivo cancer therapy.

URI

https://hdl.handle.net/11511/89477

Journal

NANOMEDICINE JOURNAL

DOI

https://doi.org/10.22038/nmj.2021.08.002

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Graduate School of Natural and Applied Sciences, Article

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Citation Formats

S. Yalcin and U. Gündüz, “Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme,” NANOMEDICINE JOURNAL, pp. 98–105, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/89477.