Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme

Date

2021-03-01

Author

Yalcin, Serap
Gündüz, Ufuk

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

192
views

0
downloads

Objective(s): In this work, MRP-1 (Multidrug resistance-associated protein 1) gene expression levels and anticancer activity of siRNA and Etoposide loaded Poly-hydroxybutyrate (PHB) coated magnetic nanoparticles (MNPs) was studied on MCF-7/Sensitive and MCF-7/1000 Etoposide resistance cells. For this purpose, PHB covered iron oxide-based magnetic nanoparticles (PHB-MNPs) were prepared by coprecipitation. We used magnetic nanoparticles because they include highly targeted to tumors in vivo cancer therapy.

URI

https://hdl.handle.net/11511/89477

Journal

NANOMEDICINE JOURNAL

DOI

https://doi.org/10.22038/nmj.2021.08.002

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Zeuner, RA; Verthelyi, D; Gürsel, Mayda; Ishii, KJ; Klinman, DM (Wiley, 2003-06-01) Objective. To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis. Methods. Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored. Results. Systemic delivery of CpG ODNs significantly increased susceptibility to local inflammation, whereas syst...
Use of the CY-PSPP in other cultures: a preliminary investigation of its factorial validity for Turkish children and youth Asci, FH; Eklund, RC; Whitehead, JR; Kirazcı, Sadettin; Koca, C (Elsevier BV, 2005-01-01) Objective. Growing international interest in self-esteem research and awareness of its relevance to human well-being and motivation has led to new opportunities to evaluate the cross-national and cross-cultural generalizability of self-esteem measurement. theory, and research (Marsh, 2001). Accordingly. the purpose of this study was to evaluate a Turkish translation of the CY-PSPP.
Investigation of the tribological behaviour of electrocodeposited Ni-MoS2 composite coatings Güler, Ebru Saraloglu; Konca, Erkan; Karakaya, İshak (2017-01-01) Objective. To discuss a patient with a prenatal diagnosis of unilateral isolated femoral focal deficiency. Case. Antenatal diagnosis of unilateral isolated femoral focal deficiency was made at 20 weeks of gestation. The length of left femur was shorter than the right, and fetal femur length was below the fifth percentile. Proximal femoral focal deficiency was diagnosed. After delivery, the diagnosis was confirmed with skeletal radiographs and magnetic resonance imaging. In prenatal ultrasonographic examinat...
Use of the dynamic volume spline method to predict facial soft tissue changes associated with orthognathic surgery Ulusoy, İlkay; Sabuncuoglu, Fidan; GÖRGÜLÜ, SERKAN; ÜÇOK, CEMİLE ÖZLEM (Elsevier BV, 2010-11-01) Objective. The shape of the face can be estimated before the surgery by using 3-dimensional computer programs that provide tools to guide skill modifications. The aim of this study was to present the dynamic volume spline method to predict facial soft tissue changes after the modification of the skull associated with orthognathic surgery.
A prediction model for detrusor overactivity at ambulatory urodynamics in women with urinary incontinence Seval, Mehmet Murat; Çetinkaya, Şerife Esra; Kalafat, Erkan; Dökmeci, Fulya (2020-08-01) Objective(s): To develop a multivariable model using both clinical examination findings and validated questionnaires' scores for predicting the presence of detrusor overactivity observed during ambulatory urodynamic monitoring in women with urinary incontinence.

Citation Formats

S. Yalcin and U. Gündüz, “Synthesis and biological activity of siRNA and Etoposide with magnetic nanoparticles on drug resistance model MCF-7 Cells: Molecular docking study with MRP1 enzyme,” NANOMEDICINE JOURNAL, pp. 98–105, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/89477.