Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
The overexpression of DNA repair genes in invasive ductal and lobular breast carcinomas: Insights on individual variations and precision medicine
Date
2021-03-01
Author
Mohamed, Ruwaa
Bargal, Salma A.
Mekawy, Asmaa S.
El-Shiekh, Iman
Tunçbağ, Nurcan
Ahmed, Alaa S.
Badr, Eman
Elserafy, Menattallah
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
275
views
0
downloads
Cite This
In the era of precision medicine, analyzing the transcriptomic profile of patients is essential to tailor the appropriate therapy. In this study, we explored transcriptional differences between two invasive breast cancer subtypes; infiltrating ductal carcinoma (IDC) and lobular carcinoma (LC) using RNA-Seq data deposited in the TCGA-BRCA project. We revealed 3854 differentially expressed genes between normal ductal tissues and IDC. In addition, IDC to LC comparison resulted in 663 differentially expressed genes. We then focused on DNA repair genes because of their known effects on patients' response to therapy and resistance. We here report that 36 DNA repair genes are overexpressed in a significant number of both IDC and LC patients' samples. Despite the upregulation in a significant number of samples, we observed a noticeable variation in the expression levels of the repair genes across patients of the same cancer subtype. The same trend is valid for the expression of miRNAs, where remarkable variations between patients' samples of the same cancer subtype are also observed. These individual variations could lie behind the differential response of patients to treatment. The future of cancer diagnostics and therapy will inevitably depend on high-throughput genomic and transcriptomic data analysis. However, we propose that performing analysis on individual patients rather than a big set of patients' samples will be necessary to ensure that the best treatment is determined, and therapy resistance is reduced.
URI
https://hdl.handle.net/11511/90002
Journal
PLOS ONE
DOI
https://doi.org/10.1371/journal.pone.0247837
Collections
Graduate School of Informatics, Article
Suggestions
OpenMETU
Core
THE RELATIONSHIP BETWEEN NONSPECIFIC INFLAMMATION MARKERS AND COMPUTERIZED TOMOGRAPHY IMAGING IN NON-TRAUMATIC ACUTE ABDOMEN
Kozaci, Nalan; Ay, Mehmet Oguzhan; Cetinkunar, Suleyman; Soker, Gokhan; Başbuğ Erkan, Berna Burçak; Celikdemir, Alper; Acehan, Selen; Gulen, Muge; Satar, Salem (2014-01-01)
Aims: The purpose of the study was to establish whether the patients presenting with abdominal pain should undergo to contrast enhanced CT (Computed tomography). For this purpose, we have investigated the possible relationship between CRP (C-reactive protein),WBC (White blood cell), neutrophil levels and the presence of pathological findings determined on abdominal pelvic CT images.
The Effects of early maladaptive schemas on partners’ marital satisfaction: the mediating roles of schema coping styles and perceived partner responsiveness
Akkol, Selin; Karancı, Ayşe Nuray; Department of Psychology (2017)
The aims of the current study are to examine (1) the possible effects of early maladaptive schemas, schema coping styles, and perceived partner responsiveness on marital satisfaction; (2) the mediating role of avoidance coping style; (3) the mediating role of compensation schema coping style; and (4) the mediating role of perceived partner responsiveness in the relationship between schema domains (i.e. Impaired Autonomy, Disconnection, Unrelenting Standards, Impaired Limits, and Other Directedness) and mari...
The association between organizational culture and individual factors on medical practice
Saraç, Çakıl; Lajunen, Timo; Department of Psychology (2007)
The aim of the present research was to investigate the relationships between patient safety culture within hospitals and individual factors on medical practice among physicians. A total of 240 physicians from ten different hospitals completed the Medical Practice Questionnaire, Hospital Survey on Patient Safety Culture, Maslach Burnout Inventory and Eysenck Personality Questionnaire Revised- Abbreviated Form. In order to assess frequency and types of medical errors, Medical Practice Questionnaire was develo...
The Effectiveness of Psychoanalytic Psychotherapy Scale: A Psychometric Study
Özkul, Kemal; Özcan, Ece; Can, Demet; Uçar, Selin; Gençöz, Tülin (ODTÜ- AYNA Klinik Psikoloji Destek Ünitesi, 2022-6)
The purpose of the present study was to develop a psychometrically robust measure to evaluate the effectiveness of psychoanalytic psychotherapy and psychoanalysis, entitled as the "Effectiveness of Psychoanalytic Psychotherapy Scale [EPPS]". This scale was designed to assess the changes experienced by patients/analysands who undergo psychoanalytic psychotherapy or psychoanalysis. A sample of 216 individuals above the age of 18 who had been continuing their own psychoanalytic psychotherapy or psychoanalysis ...
The Effect of context luminance on contrast perception
Pamir, Zahide; Acartürk, Cengiz; Boyacı, Hüseyin; Department of Cognitive Sciences (2014)
The present study has employed psychophysics and functional magnetic resonance imaging (fMRI) methodologies. The aim of the study is to investigate the role of bottom-up and top-down processing of luminance in contrast perception. In particular, since it is thought that visual illusions occur as a result of top-down processing by means of visual context, the present study investigates how luminance in context affects contrast perception by using brightness illusion. In other words, the purpose of the study ...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
R. Mohamed et al., “The overexpression of DNA repair genes in invasive ductal and lobular breast carcinomas: Insights on individual variations and precision medicine,”
PLOS ONE
, pp. 0–0, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/90002.