Discovery of Novel Potassium Ion Channel Blocing Peptides from Scorpion Venom

Hüsnügil, Hepşen Hazal
Ağyüz, Umut
Biber, Ayşenur
Özen, Can
3rd International Congress of the Molecular Biology Association of Turkey


Discovery of non-carbohydrate inhibitors of aminoglycoside-modifying enzymes
Welch, KT; Virga, KG; Whittemore, NA; Özen, Can; Wright, E; Brown, CL; Lee, RE; Serpersu, EH (2005-11-15)
Chemical modification and inactivation of aminoglycosides by many different enzymes expressed in pathogenic bacteria are the main mechanisms of bacterial resistance to these antibiotics. In this work, we designed inhibitors that contain the 1,3-diamine pharmacophore shared by all aminoglycoside antibiotics that contain the 2-deoxystreptamine ring. A discovery library of molecules was prepared by attaching different side chains to both sides of the 1,3-diamine motif. Several of these diamines showed inhibito...
Discovery of recombining plasma inside the extended gamma-ray supernova remnant HB9
Sezer, A.; Ergin, Tülün; Yamazaki, R.; Sano, H.; Fukui, Y. (2019-11-01)
We present the results from the Suzaku X-ray Imaging Spectrometer observation of the mixed-morphology supernova remnant (SNR) HB9 (G160.9+2.6). We discovered recombining plasma (RP) in the western Suzaku observation region and the spectra here are well described by a model having collisional ionization equilibrium (CIE) and RP components. On the other hand, the X-ray spectra from the eastern Suzaku observation region are best reproduced by the CIE and non-equilibrium ionization model. We discuss possible sc...
Discovery of Structural Variations in Ancient Genomes
Söylev, Arda; Alkan, Can; Somel, Mehmet (null; 2019-10-17)
Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines
Avci, M. Ender; Keskus, Ayse Gokce; Targen, Seniye; Isilak, M. Efe; Ozturk, Mehmet; Atalay, Rengül; ADAMS, MİCHELLE; KONU KARAKAYALI, ÖZLEN (2018-01-25)
Acetylcholinesterase (AChE), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. Although in vivo Ache tumorigenicity assays in mouse are present, no established liver cancer xenograft model in zebrafish using an ache mutant background exists. Herein, we developed an embryonic zebrafish xenograft model using epithelial (Hep3B) and mesenchymal (SKHep1) liver cancer cell lines in wild-type and achesb55 sibling mutant larvae after characterization...
Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds
Kars, Meltem Demirel; Iseri, Ozlem Darcansoy; Gündüz, Ufuk; Ural, Adi Ugur; Arpaci, Fikret; Molnar, Jozsef (2006-11-01)
Backgroud: The effectiveness of chemotherapy is limited by the emergence of multidrug resistance (MDR). MDR is caused by the activity of various ATP binding cassette (ABC) transporters that pump anticancer drugs out of the cells in an ATP-dependent manner. Additionally some other cellular mechanisms of MDR have been reported. The purpose of this study was to investigate mechanisms of MDR in drug resistant MCF-7 cell lines and to modulate P-glycoprotein (P-gp) and MRP1-based MDR. Materials and Methods: Pacli...
Citation Formats
H. H. Hüsnügil, U. Ağyüz, A. Biber, and C. Özen, “Discovery of Novel Potassium Ion Channel Blocing Peptides from Scorpion Venom,” presented at the 3rd International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, 2014, Accessed: 00, 2021. [Online]. Available: