Zn-doped hydroxyapatite in biomedical applications

Date

2021-03-01

Author

Uysal, Idil
Yilmaz, Bengi
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

274
views

0
downloads

Hydroxyapatite, (Ca-10(PO4)(6)(OH)(2)), is a ceramic material similar to the inorganic part of the bone and can be synthesized in a laboratory environment with different methods. The structure of HA enables ionic substitutions that change its characteristics especially in terms of biological, antibacterial, and mechanical properties. Among the ions doped into HA structure, zinc (Zn), an essential trace element in the body, is also an important dopant for biomedical applications due to its positive effect on the biological and antibacterial properties of HA. Therefore, Zn-doped HA has been extensively studied as a coating material as well as a constituent of composites and tissue engineering scaffolds. This review summarizes the synthesis methods, sintering parameters, and morphology of crystals formed in Zn-doped HAs. The lattice parameters, crystal size, and phase composition and specific Fourier-transform infrared spectroscopy (FTIR) bands detected for Zn-doped HA were collected. The proliferation and differentiation of stem cells and the functional activities of osteoblastic cells were generally shown to be enhanced on Zn-doped HA when compared with pure HA. Since the number of studies on mechanical properties of Zn-doped HA is limited, there will be a need for more studies in the future. This review also covers co-doping of Zn2+ with Ag+, Sr2+, Mg2+, Cu2+, Fe3+, Si2+, Zr4+, F-, Cl-, CO32-, SeO32-, and SiO44- ions into the structure of HA. Computational studies to predict the locations of substitution of Zn2+ and mechanical properties, such as bulk modulus, shear modulus, Young's modulus, and Poisson's ratio, were also discussed.

URI

https://hdl.handle.net/11511/90376

Journal

JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY

DOI

https://doi.org/10.1007/s41779-021-00583-4

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

ZnO Nanorods as Antireflective Coatings for Industrial-Scale Single-Crystalline Silicon Solar Cells AURANG, Pantea; Demircioglu, Olgu; ES, FIRAT; Turan, Raşit; Ünalan, Hüsnü Emrah (Wiley, 2013-04-01) In this work, both planar and textured, industrial scale (156mmx156mm) single-crystalline silicon (Si) solar cells have been fabricated using zinc oxide (ZnO) nanorods as antireflection coating (ARC). ZnO nanorods were grown in a few minutes via hydrothermal method within a commercially available microwave oven. Relative improvement in excess of 65% in the reflectivity was observed for both planar and textured Si surfaces. Through ZnO nanorods, effective lifetime (eff) measurements were presented to investi...
Co-doped hydroxyapatites as potential materials for biomedical applications YILMAZ, BENGİ; ALSHEMARY, AMMAR ZEIDAN GHAILAN; Evis, Zafer (2019-01-01) Hydroxyapatite (HA) is a synthetic biomaterial resembling the composition of mammalian hard tissue and thus, it is widely employed as a bone graft material, hard tissue engineering scaffold and coating layer for metallic substrates. Biological apatite is non-stoichiometric in nature. It is composed of small crystals and characterized by poor crystallinity and relatively high solubility with respect to stoichiometric HA. Chemical compositions of these crystals consist of Ca, P and trace amounts of various io...
Synthesis of Emulsion-Templated Acrylic-Based Porous Polymers: From Brittle to Elastomeric Tunc, Yeliz; Hasırcı, Nesrin; ULUBAYRAM, KEZBAN (2012-01-01) High internal phase emulsion polymers (PolyHIPEs) are novel materials that have high porosity and interconnected open-cell structure and are used in various applications such as supports for catalytic systems, media for separation of similar molecules, and scaffolds for tissue engineering. In this study, 90% porous acrylic based polyHIPE structures with various cellular structure and mechanical characteristics were developed by using stearyl acrylate (SA), isodecyl acrylate (IDA), isobornyl methacrylate (IB...
Enantioselective michael addition of 1-nitropropane to nitroolefins with 2-aminodmap and quinine based bifunctional organocatalysts Kanberoğlu, Esra; Tanyeli, Cihangir; Department of Chemistry (2015) 1,3-dinitro compounds are key materials in the synthesis of a variety of important fine chemicals. Moreover, they are reduced to 1,3-diamines which are starting materials of biologically active compounds, agrochemicals and pharmaceuticals. In this study, ((2S,3S)-1,3-dinitropentan-2-yl)benzene was synthesized via the Michael addition of 1-nitropropane to trans-β-nitrostyrene in the presence of chiral bifunctional 2-aminoDMAP and quinine based organocatalysts. In the first part of study, reaction conditions ...
Modification of Acrylic Bone Cements with Oxygen Plasma and Additives Endoğan Tanır, Tuğba; Kızıltay, Aysel; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2012-09-01) Acrylic bone cements which are commonly used for the fixation of orthopedic prostheses, were prepared at different formulations, by using either ground poly(methyl methacrylate) (PMMA) particles or homogeneously synthesized PMMA microspheres with application of plasma and addition of various ingredients in order to improve mechanical and thermal properties. PMMA powders having three different particle size (ground and sieved particles with 0-50 mu m (BC1 group, average particle size: 21 mu m) and 50-150 mu ...

Citation Formats

I. Uysal, B. Yilmaz, and Z. Evis, “Zn-doped hydroxyapatite in biomedical applications,” JOURNAL OF THE AUSTRALIAN CERAMIC SOCIETY, pp. 0–0, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/90376.