Additive manufacturing of biodegradable magnesium implants and scaffolds: Review of the recent advances and research trends

Sezer, Nurettin
Evis, Zafer
Koc, Muammer
Synthetic grafting needs improvements to eliminate secondary surgeries for the removal of implants after healing of the defected tissues. Tissue scaffolds are engineered to serve as temporary templates, which support the affected tissue and gradually degrade through the healing period. Beside mechanical function to withstand the anatomic loading conditions, scaffolds should also provide a decent biological function for the diffusion of nutrients and oxygen to the cells, and excretion of the wastes from the cells to promote the new tissue growth and vascularization. Moreover, the degradation byproducts of the scaffolds should be safe to the human body. Development of such multifunctional scaffolds requires selection of the right material, design, and manufacturing method. Mg has been recognized as the prominent biodegradable metal with regards to its mechanical properties matching to that of human bone, degradability in the body fluid, and its ability to stimulate new tissue growth. Scaffolds with intricate porous structures can be designed according to the patient-specific anatomic data using computer aided designs. Additive manufacturing (AM) is the right method to materialize these models rapidly with reasonably acceptable range of dimensional accuracy. Thus, the recent research trend is to develop ideal scaffolds using biodegradable Mg through AM methods. This review compiles and discusses the available literature on the AM of biodegradable Mg parts from the viewpoints of material compositions, process conditions, formation quality, dimensional accuracy, microstructure, biodegradation, and mechanical properties. The current achievements are summarized together, and future research directions are identified to promote clinical applications of biodegradable Mg through the advancement of AM. (C) 2020 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.


Bioactive agent loaded hydrogel systems for dental tissue engineering applications
Atila, Deniz Hazal; Tezcaner, Ayşen; HASIRCI, VASIF; Department of Engineering Sciences (2021-9-07)
Use of tissue engineered oral restoration products is currently a popular approach for treating dental defects that adversely affect oral health in ageing populations. Among scaffolds composed of long-lasting porous ceramics and biodegradable natural or synthetic polymers with varying service lives, injectable hydrogels attract attention to regenerate dental pulp due to the capability of filling non-uniform voids such as pulp cavity. In this study, two types of injectable hydrogels were formulized by design...
Tissue engineering of full-thickness human oral mucosa
Kınıkoğlu, Beste; Hasırcı, Vasıf Nejat; Damour, Odile; Department of Biotechnology (2010)
Tissue engineered human oral mucosa has the potential to fill tissue deficits caused by facial trauma or malignant lesion surgery. It can also help elucidate the biology of oral mucosa and serve as an alternative to in vivo testing of oral care products. The aim of this thesis was to construct a tissue engineered full-thickness human oral mucosa closely mimicking the native tissue. To this end, the feasibility of the concept was tested by co-culturing fibroblasts and epithelial cells isolated from normal hu...
Selenium doped calcium phosphate biomimetic coating on Ti6Al4V orthopedic implant material for anti-cancer and anti-bacterial purposes
Yılmaz, Bengi; Evis, Zafer; Banerjee, Sreeparna; Department of Biomedical Engineering (2014)
In order to prevent recurrent osteosarcoma in patients undergone surgical resection for implant insertion and infection around implant site, which is a very common complication after surgery, it is very important to functionalize the surface. In this study, to combine the effective antioxidant and potential anti-cancer and anti-bacterial properties of selenium with the high biocompatibility and bioactivity of hydroxyapatite, selenium was added to the structure of hydroxyapatite via biomimetic method and coa...
Wet spun PCL scaffolds for tissue engineering
Malikmammadov, Elbay; Hasırcı, Nesrin; Endoğan Tanır, Tuğba; Department of Micro and Nanotechnology (2017)
Scaffolds produced for tissue engineering applications are promising alternatives to be used in healing and regeneration of injured tissues and organs. In this study, fibrous poly(ε-caprolactone) (PCL) scaffolds were prepared by wet spinning technique and modified by addition of β-tricalcium phosphate (β-TCP) and by immobilizing gelatin onto fibers. Meanwhile, gelatin microspheres carrying Ceftriaxone sodium (CS), a model antibiotic, were added onto the scaffolds and antimicrobial activity of CS was investi...
Immobilization of heparin on chitosan-grafted polyurethane films to enhance anti-adhesive and antibacterial properties
Kara, Filiz; AKSOY, EDA AYŞE; ÇALAMAK, SEMİH; Hasırcı, Nesrin; AKSOY, SERPİL (2016-01-01)
Infections caused by bacteria adhering to implant surfaces are one of the main reasons for the failure of the implants. In this study, polyurethane (PU), which is the most commonly used polymer in the production of medical devices, was synthesized and surfaces of polyurethane films were modified by chitosan (CH) grafting and heparin (Hep) immobilization in order to enhance anti-adhesiveness and antibacterial properties. Functional groups present on the surface, topographical shapes, and free energies of the...
Citation Formats
N. Sezer, Z. Evis, and M. Koc, “Additive manufacturing of biodegradable magnesium implants and scaffolds: Review of the recent advances and research trends,” JOURNAL OF MAGNESIUM AND ALLOYS, pp. 392–415, 2021, Accessed: 00, 2021. [Online]. Available: