Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.

Sen, Edanur
Kota, Krishna P
Panchal, Rekha G
Bavari, Sina
Kiriş, Erkan


Screening and characterization of catalytic composite membranes for ethyllactate production
Oğuzer, Özge; Karakaş, Gürkan; Department of Chemical Engineering (2004)
In this research, molybdophosphoric acid (PMo) was blended with polysulfone polymer (PSF) and form a film catalyst by using a common solvent dimethylformamide (DMF). Kinetic and mass transfer parameters were evaluated for catalytic films in ethanol lactic acid esterification reaction as film surface area, film thickness and catalyst loading were varied at 50?C, 1 atm and 1:1 ethyl alcohol to lactic acid mole ratio conditions. Also prepared films were characterized by DSC, TGA, FTIR, X-ray and SEM analysis. ...
Screening of Corchorus olitorius L. extracts for antioxidant and antibacterial activities
Iseri, Ozlem Darcansoy; Korpe, Didem Aksoy; ŞAHİN, FERİDE İFFET; Cabi, Evren; Haberal, Mehmet (2011-09-01)
Investigation of cellular responses in a patient with STAT1 gain-of-function mutation successfully transplanted with Ruxolitinib bridge therapy and characterization of anti-viral immune responses in DOCK8 deficiency
Kayaoğlu, Başak; Muyan, Mesut; Department of Biology (2023-1)
Gain-of-function mutations (GOF) in the STAT1 gene are associated with impaired STAT1 phosphorylation/dephosphorylation cycle and Th17 deficiency. A sporadic T835M mutation in the STAT1 gene was detected in a patient with chronic mucocutaneous candidiasis (CMC), viral and bacterial infections accompanied by autoimmunity. Here, we aimed to investigate the cellular level defects in the patient and how they were affected by Ruxolitinib treatment and hematopoietic stem cell transplantation (HSCT). We showed tha...
Analysis and characterization of the pichia pastoris secretome for pharmaceutical protein production
Kırlı, Hatice Pınar; Koku, Harun; Department of Chemical Engineering (2019)
Human growth hormone (hGH) is used for the treatment of many diseases like short stature in children. It is generally purified by using affinity chromatography. Due to the high cost of affinity chromatography, other chromatographic techniques have been investigated for purification of recombinant human growth hormone (rhGH). The aim of this work was to explore chromatographic purification protocols for rhGH from the secretome of Pichia pastoris. First, the entire secretome was examined by 2-D gel electropho...
Investigating of oral constraceptives effects on weight gaining mechanisms in polycystic ovary sendrome (PCOS) patients
Yanık, Tülin; Yildiz, Bulent Okan (2010-08-01)
Citation Formats
E. Sen, K. P. Kota, R. G. Panchal, S. Bavari, and E. Kiriş, “Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.,” Frontiers in pharmacology, vol. 12, pp. 763950–763950, 2021, Accessed: 00, 2021. [Online]. Available: