SNR and total acquisition time analysis of multi-echo FLASH pulse sequence for current density imaging

Date

2021-12-01

Author

Sadighi, Mehdi
Şişman, Mert
Eyüboğlu, Behçet Murat

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Magnetic Resonance Current Density Imaging (MRCDI) is an imaging modality providing cross-sectionalcurrent densityðJ Þinformation inside the body. The clinical applicability of MRCDI is highly dependenton the sensitivity of the acquired noisy current-induced magnetic flux densityðB zÞdistributions.Here, a novel analysis is developed to investigate the combined effect of relevant parameters of the RFspoiled gradient echo (FLASH) pulse sequence on the SNR level and the total acquisition time (TAT) of theacquiredB zimages. The proposed analysis then is expanded for a multi-echo FLASH (ME-FLASH) pulsesequence to take advantage of combining the multiple echoes to achieveB combzdistribution with a higherSNR than the one achievable with a single echo acquisition.The optimized sequence parameters to acquire aB zdistribution with the highest possible SNR for agiven acquisition time or the desired SNR in the shortest scan time are estimated using the proposedanalysis. The analysis also provides different sets of sequence parameters to acquireB zdistributions withthe same SNR at almost the same TAT. Furthermore, the effects of intensive utilization of the gradientsand the magnetohydrodynamic (MHD) flow velocity on the acquiredB zdistribution in MRCDI experi-ments is investigated.The analytical results of the proposed analysis are validated experimentally using an imaging phantomhaving the conductivity and the relaxation parameters of the brain white matter tissue.

URI

https://doi.org/10.1016/j.jmr.2021.107098
https://hdl.handle.net/11511/94388

Journal

Journal Of Magnetic Resonance

DOI

https://doi.org/10.1016/j.jmr.2021.107098

Collections

Department of Electrical and Electronics Engineering, Article

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Citation Formats

M. Sadighi, M. Şişman, and B. M. Eyüboğlu, “SNR and total acquisition time analysis of multi-echo FLASH pulse sequence for current density imaging,” Journal Of Magnetic Resonance, vol. 333, no. 12, pp. 1–15, 2021, Accessed: 00, 2021. [Online]. Available: https://doi.org/10.1016/j.jmr.2021.107098.