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2022-10

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Orta Doğu Teknik Üniversitesi , Enformatik Enstitüsü

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Glucose-6-phosphate dehydrogenase (G6PD, E.C. 1.1.1.49) is a ubiquitous enzyme that has a housekeeping role in all cells. This enzyme catalyzes the first step in the pentose phosphate pathway (PPP) converting glucose 6-phosphate (G6P) to produce 6- phosphogluconolactone with concomitant reduction of oxidized nicotinamide adenine dinucleotide phosphate (NADP+) to reduced nicotinamide adenine dinucleotide phosphate (NADPH). NADPH plays a key role in protecting cells against oxidative stress by regulating the level of reduced glutathione (GSH) (Hwang et al., 2018). In red blood cells (RBCs), G6PD is the only source for NADPH that is important for defense against oxidative stress If the NADPH concentration in the RBCs cannot be maintained, as in G6PD deficiency (G6PDD), the GSH levels fall and oxidative damage occurs which eventually resulting in hemolytic anemia (Reading et al., 2016). The activity of human G6PD is reduced either due to a decrease in catalytic activity or a reduction in the number of active G6PD molecules (Boonyuen et al., 2016).

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https://hibit2022.ims.metu.edu.tr
https://hdl.handle.net/11511/101347

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The International Symposium on Health Informatics and Bioinformatics

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Graduate School of Informatics, Conference / Seminar

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Citation Formats

E. E. Orta Doğu Teknik Üniversitesi, “Background,” Erdemli, Mersin, TÜRKİYE, 2022, p. 3117, Accessed: 00, 2023. [Online]. Available: https://hibit2022.ims.metu.edu.tr.