Synthesis and characterization of pure and Mg, Cu, Ag, and Sr doped calcium-deficient hydroxyapatite from brushite as precursor using the dissolution-precipitation method

Date

2023-01-01

Author

Lakrat, Mohammed
Jodati, Hossein
Mejdoubi, El Miloud
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

136
views

0
downloads

Calcium-deficient hydroxyapatite (CDHA) is an attractive biomaterial for medical applications due to its similarity with the mineral part of bones. This study presents, for the first time, the preparation of CDHA form brushite as a starting precursor through dissolution-precipitation process. To further enhance its potential in vivo performance, CDHA was doped with some biologically relevant ions such as Mg2+, Sr2+, Cu2+, and Ag+. X-ray diffraction and ATR-FTIR analyses indicated that the samples were poorly crystalline, nonstoichiometric, and nanometric. BET analysis confirmed that the CDHA powders have a high specific surface area (SSA). Furthermore, crystallinity, lattice parameters, chemical composition, and SSA were significantly influenced by the substituted ion nature. Later, prepared samples were sintered at 1000 degrees C, and the structural characterization revealed that all CDHA were unstable and transformed, into p-TCP. Overall, using brushite as a starting material and dissolution-precipitation process appears an effective approach for synthesizing CDHA for bone treatment applications.

Subject Keywords

Calcium-deficient hydroxyapatite, Brushite, Ion doping, Dissolution-precipitation, beta-tricalcium phosphate, BETA-TRICALCIUM PHOSPHATE, SUBSTITUTED HYDROXYAPATITE, PROCESS PARAMETERS, HYDROLYSIS, NANOPARTICLES, ANTIBACTERIAL, BIOMATERIALS, NANOCRYSTALS, DIHYDRATE, APATITE

URI

https://hdl.handle.net/11511/101650

Journal

POWDER TECHNOLOGY

DOI

https://doi.org/10.1016/j.powtec.2022.118026

Collections

Department of Engineering Sciences, Article

Suggestions

OpenMETU
Core

Synthesis and applications of ion incorporated amorphous calcium-magnesium carbonate Göçtü, Yağmur; Ercan, Batur; Department of Metallurgical and Materials Engineering (2023-1-18) Amorphous calcium carbonate (ACC) can be synthesized using co-precipitation technique and different ions can typically be incorporated into its amorphous structure to enhance its stability. Although ACC was investigated for various applications, its antibacterial properties have not been explored. In this thesis, two different types of magnesium stabilized amorphous calcium carbonate (ACMC) nanoparticles were synthesized for antibacterial applications. In the first part selenite ions, and in the secon...
Manufacture of macroporous calcium hydroxyapatite bioceramics Engin, NO; Tas, AC (1999-01-01) Trabecular bones of almost all vertebrate organisms basically consist of macroporous (55-70% interconnected porosity) bone mineral, i.e. calcium hydroxyapatite (HA: Ca-10(PO4)(6)(OH)(2)). The macroporosity observed in the trabecular bones then allows the ingrowth of the soft tissues and organic cells into the bone matrix. Sub-micron, chemically uniform, and high phase-purity HA powders produced in our laboratory were mixed, under vigorous ultrasonification, with methyl cellulose of appropriate amounts in th...
Synthesis and characterization of whitlockite from sea urchin skeleton and investigation of antibacterial activity Yucel, Aysegul; Sezer, Selda; BİRHANLI, EMRE; Ekinci, Tuba; Yalman, Emine; Depci, Tolga (2021-01-01) In the present study, undoped whitlockite and ZnO doped-Whitlockite, which is the second most abundant inorganic material in bone structure, were synthesized from sea urchin skeleton. The obtained bioceramic ma-terials were characterized by XRD, FT-IR, and SEM and their antibacterial activities were determined using the inhibition zone diameters of Escherichia coli and Pseudomonas aeruginosa as gram negative bacteria and Staphylococcus aureus as gram positive bacterium after 24 h incubation. The characteriz...
Preparation of anti-adhesive and antibacterial surfaces using polymers Onat, Bora; İErel Göktepe, İrem; Banerjee, Sreeparna; Department of Biotechnology (2017) Layer-by-layer self-assembly of polymers is a versatile technique which can impart new functions to the surfaces of biomedical instruments and biomaterials. Materials which are coated by this technique can exhibit response towards environmental stimuli, such that the controlled release of drugs and similar biologically functional molecules under different stimuli can be observed. In the span of this thesis study, ultra-thin polymer films were prepared through the layer-by-layer self-assembly technique, the ...
Synthesis and sintering of B, Sr, Mg multi-doped hydroxyapatites: Structural, mechanical and biological characterization Yedekçi, Buşra; Tezcaner, Ayşen; DEMİR, TEYFİK; Evis, Zafer (2021-03-01) Hydroxyapatite (HA, Ca-10(PO4)(6)(OH)(2)) is the main constituent mineral of bone and teeth in mammals. Due to its outstanding biocompatibility and osteoconductive capabilities, it is preferred for bone repair and replacement. Owing to high potential to have excellent biological properties, ternary ions-doped HAs have just begun to be investigated in the biomedical field and preparing multi-doped HAs is a fairly new approach. Boron (B, BO33-), strontium (Sr, Sr2+) and magnesium (Mg, Mg2+) provide a benefici...

Citation Formats

M. Lakrat, H. Jodati, E. M. Mejdoubi, and Z. Evis, “Synthesis and characterization of pure and Mg, Cu, Ag, and Sr doped calcium-deficient hydroxyapatite from brushite as precursor using the dissolution-precipitation method,” POWDER TECHNOLOGY, vol. 413, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://hdl.handle.net/11511/101650.