Synthesis and applications of ion incorporated amorphous calcium-magnesium carbonate

Göçtü, Yağmur
Amorphous calcium carbonate (ACC) can be synthesized using co-precipitation technique and different ions can typically be incorporated into its amorphous structure to enhance its stability. Although ACC was investigated for various applications, its antibacterial properties have not been explored. In this thesis, two different types of magnesium stabilized amorphous calcium carbonate (ACMC) nanoparticles were synthesized for antibacterial applications. In the first part selenite ions, and in the second part zinc and strontium ions were incorporated into the ACMC nanoparticles. It was shown that ion incorporated ACMC nanoparticles maintained their amorphous structure. The synthesized nanoparticles inhibited bacterial growth of several bacteria strains. 0.01, 0.005 and 0.001 M selenite incorporated ACMC nanoparticles prepared at 1 g/L concentration significantly inhibited the growth of gram-positive Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) and gram-negative Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) strains after 24 h of interaction. The antibacterial activity was shown to enhance as the amount of incorporated selenite was increased. On the other hand, zinc and/or strontium incorporated (0.1 and 0.01 M) ACMC nanoparticles prepared at 0.01 g/L concentration exerted antibacterial activity towards S. aureus, and the extend of this antibacterial activity could also be enhanced by ion concentration, where higher amounts (0.1 M) of Zn and Sr incorporated ACMC nanoparticles were able to decrease the growth of E. coli. In summary, in this thesis study, non-toxic and biodegradable nanoparticles were fabricated by incorporating selenite, zinc and strontium into ACMC for antibacterial applications. Results showed that ion incorporated ACMC is a potential candidate to fight with bacteria.


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Citation Formats
Y. Göçtü, “Synthesis and applications of ion incorporated amorphous calcium-magnesium carbonate,” M.S. - Master of Science, Middle East Technical University, 2023.