The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study

Download

1-s2.0-S0924977X22008379-main.pdf

Date

2022-10-01

Author

Fusar-Poli, Laura
Pries, Lotta-Katrin
van Os, Jim
Radhakrishnan, Rajiv
Pençe, Ayşegül Yay
Erzin, Gamze
Delespaul, Philippe
Kenis, Gunter
Luykx, Jurjen J
Lin, Bochao D
Akdede, Berna
Binbay, Tolga
Altınyazar, Vesile
Yalınçetin, Berna
Gümüş-Akay, Güvem
Cihan, Burçin
Soygür, Haldun
Ulaş, Halis
Cankurtaran, Eylem Şahin
Kaymak, Semra Ulusoy
Mihaljevic, Marina M
Andric-Petrovic, Sanja
Mirjanic, Tijana
Bernardo, Miguel
Mezquida, Gisela
Amoretti, Silvia
Bobes, Julio
Saiz, Pilar A
García-Portilla, Maria Paz
Sanjuan, Julio
Aguilar, Eduardo J
Santos, José Luis
Jiménez-López, Estela
Arrojo, Manuel
Carracedo, Angel
López, Gonzalo
González-Peñas, Javier
Parellada, Mara
Maric, Nadja P
Atbaşoğlu, Cem
Üçok, Alp
Alptekin, Köksal
Saka, Meram Can
Aguglia, Eugenio
Arango, Celso
Rutten, Bart PF
Guloksuz, Sinan

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

145
views

68
downloads

Schizophrenia is frequently accompanied with social cognitive disturbances. Cannabis represents one established environmental factor associated with the onset and progression of schizophrenia. The present cross-sectional study aimed to investigate the association of facial emotion recognition (FER) performance with cannabis use in 2039 patients with schizophrenia, 2141 siblings, and 2049 healthy controls (HC). FER performance was measured using the Degraded Facial Affect Recognition Task (DFAR). Better FER performance as indicated by higher DFAR-total scores was associated with lifetime regular cannabis use in schizophrenia (B = 1.36, 95% CI 0.02 to 2.69), siblings (B = 2.17, 95% CI 0.79 to 3.56), and HC (B = 3.10, 95% CI 1.14 to 5.06). No associations were found between DFAR-total and current cannabis use. Patients with schizophrenia who started to use cannabis after the age of 16 showed better FER performance than patients who started earlier (B = 2.50, 95% CI 0.15 to 4.84) and non-users (B = 3.72, 95 CI 1.96 to 5.49). Better FER performance was found also in siblings who started to use cannabis after 16 compared to non-users (B = 2.37, 95% CI 0.58 to 4.16), while HC using cannabis performed better than non-users at DFAR-total regardless of the age at onset. Our findings suggest that lifetime regular cannabis use may be associated with better FER regardless of the psychosis risk, but that FER might be moderated by age at first use in people with higher genetic risk. Longitudinal studies may clarify whether there is a cause-and-effect relationship between cannabis use and FER performance in psychotic and non-psychotic samples.

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138531826&origin=inward
https://hdl.handle.net/11511/101666

Journal

European Neuropsychopharmacology

DOI

https://doi.org/10.1016/j.euroneuro.2022.08.003

Collections

Department of Psychology, Article

Suggestions

OpenMETU
Core

The Relationship Between Illness Duration And Brain Morphometry in Schizophrenia: Heschl's Gyrus and Prefrontal Cortex Volumetry KARABAY, NURİ; ÖNİZ, ADİLE; Gökçay, Didem; ALPTEKİN, KÖKSAL; Hugdahl, Kenneth; ÖZGÖREN, MURAT (2013-01-01) Introduction: The relationship between brain morphology and illness duration has been observed as a biomarker in psychiatric and neurologic patients, especially in schizophrenia. In this study, we aimed to investigate the relationship between the volumes of two target regions [prefrontal cortex (PFC) and Heschl's gyrus (HG)] and illness duration in schizophrenia. Such measurements can have implications for then understanding of cognitive impairments in schizophrenia.
The Well-being of siblings of patients with schizophrenia : an evaluation within the transactional stress and coping model Yüksel, Muazzez Merve; Karancı, Ayşe Nuray; Department of Psychology (2013) Schizophrenia is a chronic mental illness which strongly affects not only schizophrenia patients, but also their families and close relatives. So far, family research on patients with schizophrenia has focused on parents, but has neglected siblings.The present study aims to evaluate the well-being of the siblings of patients with schizophrenia within the Lazarus & Folkman’s Transactional Coping and Stress Model. The sample consisted of 103 well siblings of schizophrenia patients. In the present study Socio-...
Detection of hypothalamic neuropeptite levels involved in appetite regulation in aripiprazole treatment / Özdemir, Serhat; Yanık, Tülin; Department of Biotechnology (2014) Disruption or malfunctioning of neurotransmitter pathways, especially serotonergic and dopaminergic pathways are closely related to psychotic disorders such as schizophrenia. Antipsychotic medications are becoming widespread; however, in long term treatments, these drugs lead to considerable amount of weight gain as a side effect. Metformin, an antidiabetic drug, has previously been used to treat antipsychotic induced weight gain and aripiprazole has been defined as a neutral antipsychotic drug in terms of ...
The Distinctive Associations of Interpersonal Problems with Personality Beliefs Within the Framework of Cognitive Theory of Personality Disorders Akyunus, Miray; Gençöz, Tülin (Springer Science and Business Media LLC, 2020-03-01) The aim of this study was to explore the relationship between interpersonal problems and dysfunctional beliefs associated with personality disorders, within the framework of cognitive theory of personality disorders. Based on the proposition of cognitive theory, different dimensions of interpersonal problems which were assessed through the coordinates of interpersonal circumplex model were expected to be associated with specific categories of personality beliefs namely, deprecating, inflated, and ambivalent...
The effects of brief psychoeducation program on the perceived expressed emotion levels of the outpatient schizophrenic patients and expressed emotion levels and burn out levels of their key relatives Yüksel, Muazzez Merve; Karancı, Ayşe Nuray; Department of Psychology (2008) The main aim of this study is to investigate the effects of a brief psycho-educational intervention for the key relatives of schizophrenic patients, on perceived expressed emotion of patients, and the expressed emotion and burn out of their key relatives. Seventy five schizophrenic patients and their key relatives were included in the study. They were assigned into three groups randomly. The key relatives in the first experimental group were given a one-day psychoeducational workshop and written material pa...

Citation Formats

L. Fusar-Poli et al., “The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls: Results from the EUGEI study,” European Neuropsychopharmacology, vol. 63, pp. 47–59, 2022, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85138531826&origin=inward.